Nod2–Rip2 Signaling Contributes to Intestinal Injury Induced by Muramyl Dipeptide Via Oligopeptide Transporter in Rats
| العنوان: | Nod2–Rip2 Signaling Contributes to Intestinal Injury Induced by Muramyl Dipeptide Via Oligopeptide Transporter in Rats |
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| المؤلفون: | Hong-ze Zhang, Sheng-xia Wan, Jingquan Liu, Guoguang Ma, Zijun YinTao, Xiaoli Lou, Bin Shi, Yanqiang Hou, Dong-Yu Liang, Wan-hua Yang |
| المصدر: | Digestive Diseases and Sciences. 60:3264-3270 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Physiology, Nod2 Signaling Adaptor Protein, Inflammation, Pharmacology, Peptide Transporter 1, Rats, Sprague-Dawley, Jejunum, chemistry.chemical_compound, Receptor-Interacting Protein Serine-Threonine Kinase 2, NOD2, parasitic diseases, medicine, Animals, Intestinal Mucosa, Oligopeptide, Dipeptide, Symporters, biology, Glycylglycine, Chemistry, Peptide transporter 1, NF-kappa B, Gastroenterology, Enteritis, Small intestine, body regions, medicine.anatomical_structure, Biochemistry, biology.protein, Cytokines, Inflammation Mediators, medicine.symptom, Acetylmuramyl-Alanyl-Isoglutamine, Muramyl dipeptide, Signal Transduction |
| الوصف: | PepT1 can transport bacterial oligopeptide products and induce intestinal inflammation. Our aim was to investigate the mechanism of the small intestine injury induced by bacterial oligopeptide product muramyl dipeptide (MDP) which is transported by PepT1. We perfused the jejunum with a solution with or without MDP, or with a solution of MDP + Gly-Gly and explored the degree of inflammation to determine the role of PepT1–Nod2 signaling pathway in small intestine mucosa. MDP perfusion induced inflammatory cell accumulation and intestinal damage, accompanied by an increase in mucosal Nod2 and Rip2 transcript expression. NFκB activity and inflammatory cytokine expression, including serum levels of TNF-α, IL-1β, and IL-6, increased in the MDP group compared to the controls; these effects were reversed by perfusion of the nutritional dipeptide Gly-Gly. MDP can be transported through PepT1, causing inflammatory damage in the rat small intestine. Nod2–Rip2–NFκB signaling involved in the small intestinal inflammatory injury caused by MDP which is transported through PepT1. |
| تدمد: | 1573-2568 0163-2116 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de80c4d94cecef8b2cea4e55736df80 https://doi.org/10.1007/s10620-015-3762-1 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....5de80c4d94cecef8b2cea4e55736df80 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15732568 01632116 |
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