A regulatory role for CD37 in T cell proliferation
| العنوان: | A regulatory role for CD37 in T cell proliferation |
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| المؤلفون: | Klaus-Peter Knobeloch, Annemiek B. van Spriel, Magdalena Plebanski, Zane Orinska, Mark D. Wright, Kirsten L. Puls, Dodie S. Pouniotis, Hubertus Hochrein, Mariam Sofi |
| المصدر: | Journal of Immunology, 172, 5, pp. 2953-61 Journal of Immunology, 172, 2953-61 |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Naive T cell, Tetraspanins, T cell, Immunology, CD4-CD8 Ratio, Down-Regulation, Apoptosis, Mice, Transgenic, chemical and pharmacologic phenomena, Cell Separation, CD8-Positive T-Lymphocytes, Biology, Mice, Interleukin 21, Antigens, CD, Antigens, Neoplasm, T-Lymphocyte Subsets, medicine, Animals, Humans, Immunology and Allergy, Cytotoxic T cell, IL-2 receptor, Antigen-presenting cell, Glycoproteins, Mice, Knockout, Mice, Inbred BALB C, ZAP70, CD28, Immunotherapy, gene therapy and transplantation [UMCN 1.4], Growth Inhibitors, Up-Regulation, Cell biology, Mice, Inbred C57BL, medicine.anatomical_structure, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Receptor-CD3 Complex, Antigen, T-Cell, Cancer research, Cytokines, Immunologic Memory, Cell Division, Signal Transduction |
| الوصف: | Contains fulltext : 57476.pdf (Publisher’s version ) (Closed access) CD37 is a leukocyte-specific protein belonging to the tetraspanin superfamily. Previously thought to be predominantly a B cell molecule, CD37 is shown in this study to regulate T cell proliferation. CD37-deficient (CD37(-/-)) T cells were notably hyperproliferative in MLR, in response to Con A, or CD3-TCR engagement particularly in the absence of CD28 costimulation. Hyperproliferation was not due to differences in memory to naive T cell ratios in CD37(-/-) mice, apoptosis, or TCR down-modulation. Division cycle analyses revealed CD37(-/-) T cells to enter first division earlier than wild-type T cells. Importantly, proliferation of CD37(-/-) T cells was preceded by enhanced early IL-2 production. We hypothesized CD37 to be involved in TCR signaling and this was supported by the observation that CD4/CD8-associated p56(Lck) kinase activity was increased in CD37(-/-) T cells. Remarkably, CD37 cross-linking on human T cells transduced signals that led to complete inhibition of CD3-induced proliferation. In the presence of CD28 costimulation, CD37 engagement still significantly reduced proliferation. Taken together, these results demonstrate a regulatory role for CD37 in T cell proliferation by influencing early events of TCR signaling. |
| وصف الملف: | application/pdf |
| تدمد: | 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de818e6763641c8fbfdbd4dad0d6a61 https://hdl.handle.net/2066/57476 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5de818e6763641c8fbfdbd4dad0d6a61 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00221767 |
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