Temporal Changes in Cardiac Troponin I Are Associated with Risk of Cardiovascular Events in the General Population: The Nord-Trøndelag Health Study
| العنوان: | Temporal Changes in Cardiac Troponin I Are Associated with Risk of Cardiovascular Events in the General Population: The Nord-Trøndelag Health Study |
|---|---|
| المؤلفون: | Magnus Nakrem Lyngbakken, Kristian Hveem, Torbjørn Omland, Helge Røsjø, Oddgeir L. Holmen, Håvard Dalen |
| المصدر: | Clinical Chemistry. 65:871-881 |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Clinical Biochemistry, Population, macromolecular substances, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Medicine, cardiovascular diseases, 030212 general & internal medicine, Myocardial infarction, education, education.field_of_study, business.industry, Proportional hazards model, Biochemistry (medical), Hazard ratio, musculoskeletal system, medicine.disease, Blood pressure, Heart failure, cardiovascular system, Cardiology, Myocardial infarction diagnosis, business, Cohort study |
| الوصف: | BACKGROUND Cardiac troponins are associated with cardiovascular risk in the general population, but whether temporal changes in cardiac troponin I provide independent prognostic information remains uncertain. Using a large community-based cohort with follow-up close to the present day, we aimed to investigate the associations between temporal changes in cardiac troponin and cardiovascular events. METHODS We measured cardiac troponin I with a high-sensitivity assay (hs-cTnI) in 4805 participants attending both the second (HUNT 2, 1995–97) and third wave (HUNT 3, 2006–2008) of the prospective observational Nord-Trøndelag Health (HUNT) Study. We constructed statistical models with both relative and absolute changes of hs-cTnI from HUNT 2 to HUNT 3. A composite end point of cardiovascular death or first admission for myocardial infarction or heart failure was generated. RESULTS Participants with relative decrease in hs-cTnI were more frequently younger and female and had lower blood pressure and body mass index. Participants with relative increase in hs-cTnI more frequently were older and male, with higher systolic blood pressure. The adjusted hazard ratio (HR) for relative increase in hs-cTnI was 1.68 (95% CI, 1.16–2.42) and the adjusted HR for relative decrease was 1.19 (95% CI, 0.84–1.68). Absolute increases in hs-cTnI exhibited similar prognostic properties as relative increases in hs-cTnI. The most recent measurement of hs-cTnI outperformed the change variables in discrimination and reclassification models. CONCLUSIONS Both relative and absolute increases in hs-cTnI are independently associated with cardiovascular risk. For refinement of risk prediction models, the most recent measurement of hs-cTnI should be preferred in clinical practice. |
| تدمد: | 1530-8561 0009-9147 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8456027a43e70d5790e133dbefcfba https://doi.org/10.1373/clinchem.2018.301069 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5e8456027a43e70d5790e133dbefcfba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15308561 00099147 |
|---|