Rapamycin Preconditioning Attenuates Transient Focal Cerebral Ischemia/Reperfusion Injury in Mice
| العنوان: | Rapamycin Preconditioning Attenuates Transient Focal Cerebral Ischemia/Reperfusion Injury in Mice |
|---|---|
| المؤلفون: | Yao-ying Zeng, Le-le Yin, Zhen Chen, Sha-sha Ye |
| المصدر: | International Journal of Neuroscience. 122:748-756 |
| بيانات النشر: | Informa UK Limited, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Brain Infarction, Male, Traumatic brain injury, Ischemia, Apoptosis, Brain Edema, Pharmacology, Hippocampus, Mice, Animals, Medicine, Middle cerebral artery occlusion, Survival rate, bcl-2-Associated X Protein, Neurologic Examination, Sirolimus, Mice, Inbred BALB C, Tumor Necrosis Factor-alpha, business.industry, Brain edema, General Neuroscience, NF-kappa B, Infarction, Middle Cerebral Artery, General Medicine, medicine.disease, Survival Rate, Disease Models, Animal, Gene Expression Regulation, Reperfusion Injury, Anesthesia, Female, Nervous System Diseases, Neurological deficit score, business, Reperfusion injury |
| الوصف: | Rapamycin, an mTOR inhibitor and immunosuppressive agent in clinic, has protective effects on traumatic brain injury and neurodegenerative diseases. But, its effects on transient focal ischemia/reperfusion disease are not very clear. In this study, we examined the effects of rapamycin preconditioning on mice treated with middle cerebral artery occlusion/reperfusion operation (MCAO/R). We found that the rapamycin preconditioning by intrahippocampal injection 20 hr before MCAO/R significantly improved the survival rate and longevity of mice. It also decreased the neurological deficit score, infracted areas and brain edema. In addition, rapamycin preconditioning decreased the production of NF-κB, TNF-α, and Bax, but not Bcl-2, an antiapoptotic protein in the ischemic area. From these results, we may conclude that rapamycin preconditioning attenuate transient focal cerebral ischemia/reperfusion injury and inhibits apoptosis induced by MCAO/R in mice. |
| تدمد: | 1543-5245 0020-7454 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e87a38925b69d141785ddde661250da https://doi.org/10.3109/00207454.2012.721827 |
| رقم الأكسشن: | edsair.doi.dedup.....5e87a38925b69d141785ddde661250da |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15435245 00207454 |
|---|