Paralysis elicited by spinal cord injury evokes selective disassembly of neuromuscular synapses with and without terminal sprouting in ankle flexors of the adult rat
| العنوان: | Paralysis elicited by spinal cord injury evokes selective disassembly of neuromuscular synapses with and without terminal sprouting in ankle flexors of the adult rat |
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| المؤلفون: | Srishti Bhagat, Sabiha Jawaid, Anthony S. Burns, Young-Jin Son, Alan Tessler, Hui Zhong, Marion Murray, Hiroyuki Yoshihara, Roland R. Roy |
| المصدر: | The Journal of Comparative Neurology. 500:116-133 |
| بيانات النشر: | Wiley, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Time Factors, animal structures, Neuromuscular Junction, Presynaptic Terminals, Schwann cell, Nerve Tissue Proteins, Biology, Models, Biological, Neuromuscular junction, Rats, Sprague-Dawley, Postsynaptic potential, Physical Conditioning, Animal, medicine, Paralysis, Animals, Receptors, Cholinergic, Spinal cord injury, Spinal Cord Injuries, Acetylcholine receptor, Analysis of Variance, Membrane Glycoproteins, General Neuroscience, S100 Proteins, Anatomy, musculoskeletal system, Spinal cord, medicine.disease, Immunohistochemistry, Nerve Regeneration, Rats, medicine.anatomical_structure, nervous system, Synapse disassembly, Female, Schwann Cells, Ankle, medicine.symptom, Neuroscience |
| الوصف: | Neuromuscular junctions (NMJs) innervated by motor neurons below spinal cord injury (SCI) have been reported to remain intact despite the interruption of supraspinal pathways and the resultant loss of activity. Here we report notably heterogeneous NMJ responses to SCI that include overt synapse disassembly. Complete transection of the thoracic spinal cord of adult rats evoked massive sprouting of nerve terminals in a subset of NMJs in ankle flexors, extensor digitorum longus, and tibialis anterior. Many of these synapses were extensively disassembled 2 weeks after spinal transection but by 2 months had reestablished synaptic organization despite continuous sprouting of their nerve terminals. In contrast, uniform and persistent loss of acetylcholine receptors (AChRs) was evident in another subset of NMJs in the same flexors, which apparently lacked terminal sprouting and largely maintained terminal arbors. Other synapses in the flexors, and almost all the synapses in the ankle extensors, medial gastrocnemius, and soleus, remained intact, with little pre- or postsynaptic alteration. Additional deafferentation of the transected animals did not alter the incidence or regional distribution of either type of the unstable synapses, whereas cycling exercise diminished their incidence. The muscle- and synapse-specific responses of NMJs therefore reflected differential sensitivity of the NMJs to inactivity rather than to differences in residual activity. These observations demonstrate the existence of multiple subpopulations of NMJs that differ distinctly in pre- and postsynaptic vulnerability to the loss of activity and highlight the anatomical instability of NMJs caudal to SCI, which may influence motor deficit and recovery after SCI. |
| تدمد: | 1096-9861 0021-9967 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eca62adff706389e04494b2d962b33c https://doi.org/10.1002/cne.21143 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....5eca62adff706389e04494b2d962b33c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969861 00219967 |
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