The Aryl Hydrocarbon Receptor-Activating Effect of Uremic Toxins from Tryptophan Metabolism: A New Concept to Understand Cardiovascular Complications of Chronic Kidney Disease
| العنوان: | The Aryl Hydrocarbon Receptor-Activating Effect of Uremic Toxins from Tryptophan Metabolism: A New Concept to Understand Cardiovascular Complications of Chronic Kidney Disease |
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| المؤلفون: | Claire Cerini, Philippe Brunet, Marion Sallée, Stéphane Poitevin, Laetitia Dou, Stéphane Burtey |
| المساهمون: | Vascular research center of Marseille (VRCM), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Dou, Laetitia, Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU) |
| المصدر: | Toxins Toxins, Vol 6, Iss 3, Pp 934-949 (2014) Toxins, MDPI, 2014, 6 (3), pp.934-949. ⟨10.3390/toxins6030934⟩ |
| بيانات النشر: | MDPI, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.medical_specialty, Kynurenine pathway, Health, Toxicology and Mutagenesis, lcsh:Medicine, Review, 030204 cardiovascular system & hematology, Toxicology, medicine.disease_cause, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Proinflammatory cytokine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Kynurenic acid, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, tryptophan-derived uremic toxins, Internal medicine, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, medicine, Leukocytes, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Renal Insufficiency, Chronic, 030304 developmental biology, Toxins, Biological, Uremia, 0303 health sciences, biology, aryl hydrocarbon receptor, lcsh:R, Tryptophan, Aryl hydrocarbon receptor, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, cardiovascular diseases, Oxidative Stress, Endocrinology, chemistry, Receptors, Aryl Hydrocarbon, biology.protein, Endothelium, Vascular, Kynurenine, Oxidative stress, chronic kidney disease, Quinolinic acid |
| الوصف: | International audience; Patients with chronic kidney disease (CKD) have a higher risk of cardiovascular diseases and suffer from accelerated atherosclerosis. CKD patients are permanently exposed to uremic toxins, making them good candidates as pathogenic agents. We focus here on uremic toxins from tryptophan metabolism because of their potential involvement in cardiovascular toxicity: indolic uremic toxins (indoxyl sulfate, indole-3 acetic acid, and indoxyl-beta-d-glucuronide) and uremic toxins from the kynurenine pathway (kynurenine, kynurenic acid, anthranilic acid, 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid). Uremic toxins derived from tryptophan are endogenous ligands of the transcription factor aryl hydrocarbon receptor (AhR). AhR, also known as the dioxin receptor, interacts with various regulatory and signaling proteins, including protein kinases and phosphatases, and Nuclear Factor-Kappa-B. AhR activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin and some polychlorinated biphenyls is associated with an increase in cardiovascular disease in humans and in mice. In addition, this AhR activation mediates cardiotoxicity, vascular inflammation, and a procoagulant and prooxidant phenotype of vascular cells. Uremic toxins derived from tryptophan have prooxidant, proinflammatory, procoagulant, and pro-apoptotic effects on cells involved in the cardiovascular system, and some of them are related with cardiovascular complications in CKD. We discuss here how the cardiovascular effects of these uremic toxins could be mediated by AhR activation, in a ``dioxin-like'' effect. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6651 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed6864536dcf7e2c6a1c3e18fbf4bea http://europepmc.org/articles/PMC3968369 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5ed6864536dcf7e2c6a1c3e18fbf4bea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726651 |
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