التفاصيل البيبلوغرافية
| العنوان: |
Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern |
| المؤلفون: |
Dorothy E. Pazin, Stephanie M. Correa, Ravi S. Kahlon, Kenneth H. Albrecht, Hyunjoo Jean Lee |
| المصدر: |
Developmental dynamics : an official publication of the American Association of Anatomists. 238(4) |
| سنة النشر: |
2009 |
| مصطلحات موضوعية: |
Male, medicine.medical_specialty, endocrine system, Gonad, Time Factors, Down-Regulation, Ovary, Organogenesis, Tretinoin, Biology, Article, Mice, Cornified Envelope Proline-Rich Proteins, Wnt4 Protein, Internal medicine, WNT4, Gene expression, medicine, Animals, Primordium, Body Patterning, urogenital system, Gene Expression Regulation, Developmental, Embryo, Mammalian, Sex-Determining Region Y Protein, Cell biology, Wnt Proteins, medicine.anatomical_structure, Endocrinology, Testis determining factor, Female, Development of the gonads, Biomarkers, Developmental Biology, Signal Transduction |
| الوصف: |
Mammalian gonad differentiation involves sexually dimorphic cell-fate decisions within the bipotential gonadal primordia. Testis differentiation is initiated by a center-to-poles wave of Sry expression that induces supporting cell precursors (SCPs) to become Sertoli rather than granulosa cells. The initiation of ovary differentiation is less well understood. We identified two novel SCP markers, 1700106J16Rik and Sprr2d, whose expression is ovary-biased during early gonad development, and altered in Wnt4, Sf1, Wt1, and Fog2 mutant gonads. In XX and XY gonads, both genes were up-regulated at ∼E11 in a center-to-poles wave, and then rapidly down-regulated in XY gonads in a center-to-poles wave, which is reminiscent of Sry expression in XY gonads. Our data suggest that 1700106J16Rik and Sprr2d may have important roles in early gonad development, and are consistent with the hypothesis that ovarian SCP differentiation occurs in a center-to-poles wave with similar timing to that of testicular SCP differentiation. Developmental Dynamics 238:812–825, 2009. © 2009 Wiley-Liss, Inc. |
| تدمد: |
1058-8388 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee31f1bccdbff0928e79647fe923b58
https://pubmed.ncbi.nlm.nih.gov/19301398 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi.dedup.....5ee31f1bccdbff0928e79647fe923b58 |
| قاعدة البيانات: |
OpenAIRE |
