أعرض في EDS

Physiologically based pharmacokinetic modeling of intravenously administered nanoformulated substances

التفاصيل البيبلوغرافية
العنوان: Physiologically based pharmacokinetic modeling of intravenously administered nanoformulated substances
المؤلفون: Jordi Minnema, Sven Even F. Borgos, Neill Liptrott, Rob Vandebriel, Christiaan Delmaar
المساهمون: Oral and Maxillofacial Surgery / Oral Pathology
المصدر: Drug Delivery and Translational Research
Drug delivery and translational research. Springer Publishing Company
بيانات النشر: Springer Science and Business Media LLC, 2022.
سنة النشر: 2022
مصطلحات موضوعية: Kinetics, Biodistribution, Metabolic Clearance Rate, Physiologically based pharmacokinetic modeling, Animals, Pharmaceutical Science, Nanobiomaterials (NBMs), Bayes Theorem, Tissue Distribution, Bayesian parameter estimation, Models, Biological, Rats
الوصف: The use of nanobiomaterials (NBMs) is becoming increasingly popular in the field of medicine. To improve the understanding on the biodistribution of NBMs, the present study aimed to implement and parametrize a physiologically based pharmacokinetic (PBPK) model. This model was used to describe the biodistribution of two NBMs after intravenous administration in rats, namely, poly(alkyl cyanoacrylate) (PACA) loaded with cabazitaxel (PACA-Cbz), and LipImage™ 815. A Bayesian parameter estimation approach was applied to parametrize the PBPK model using the biodistribution data. Parametrization was performed for two distinct dose groups of PACA-Cbz. Furthermore, parametrizations were performed three distinct dose groups of LipImage™ 815, resulting in a total of five different parametrizations. The results of this study indicate that the PBPK model can be adequately parametrized using biodistribution data. The PBPK parameters estimated for PACA-Cbz, specifically the vascular permeability, the partition coefficient, and the renal clearance rate, substantially differed from those of LipImage™ 815. This emphasizes the presence of kinetic differences between the different formulations and substances and the need of tailoring the parametrization of PBPK models to the NBMs of interest. The kinetic parameters estimated in this study may help to establish a foundation for a more comprehensive database on NBM-specific kinetic information, which is a first, necessary step towards predictive biodistribution modeling. This effort should be supported by the development of robust in vitro methods to quantify kinetic parameters. Graphical abstract
وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/pdf
تدمد: 2190-3948
2190-393X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee8fee1e1ffb60561b27cc1d29f8acd
https://doi.org/10.1007/s13346-022-01159-w
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....5ee8fee1e1ffb60561b27cc1d29f8acd
قاعدة البيانات: OpenAIRE
الوصف
تدمد:21903948
2190393X