The daily practice reality of PD‑L1 (CD274) evaluation in non‑small cell lung cancer: A retrospective study
| العنوان: | The daily practice reality of PD‑L1 (CD274) evaluation in non‑small cell lung cancer: A retrospective study |
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| المؤلفون: | Camille Verocq, Myriam Remmelink, Sarah De Clercq, Isabelle Salmon, Laureen Rocq, Christophe Compère, Sebahat Ocak, Audrey Verrellen, Nicky D'Haene, Christine Decaestecker, Claudia Stanciu‑Pop, Zita Mekinda |
| المساهمون: | UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de pneumologie, UCL - (MGD) Service d'anatomie pathologique, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie |
| المصدر: | Oncology letters, Vol. 19, no. 5, p. 3400-3410 (2020) Oncology Letters, 19 (5 Oncology Letters |
| بيانات النشر: | Spandidos Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | PD-L1, concordance, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Concordance, NSCLC, medicine.disease_cause, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Internal medicine, Biopsy, CD274 molecule, medicine, daily practice, Lung cancer, Fisher's exact test, medicine.diagnostic_test, business.industry, Médecine pathologie humaine, Cancer, Articles, medicine.disease, Primary tumor, Cancérologie, 030104 developmental biology, Anatomopathologie, 030220 oncology & carcinogenesis, symbols, Immunohistochemistry, KRAS, business, IHC |
| الوصف: | Treatment with pembrolizumab, an anti-programmed cell death-1 (PDCD-1) monoclonal antibody for the treatment of non-small cell lung cancers (NSCLCs) requires prior immunohistochemical (IHC) analysis of the expression of the programmed death-ligand 1 (PD-L1) (also known as CD274 molecule) which is a heterogeneous and complex marker. The present study aimed to investigate how pathological and technical factors (such as tumor location and sampling type, respectively) may affect the PD-L1 evaluation in patients with NSCLC in the daily practice of pathology laboratories. The current study was retrospective, and included 454 patients with NSCLC, for whom PD-L1 expression analysis by IHC was prospectively performed between November 2016 and January 2018. The association between PD-L1 expression and the clinicopathological characteristics of patients was statistically investigated using either the χ2 and Fisher exact tests or the Mann-Whitney and Kruskal-Wallis tests, depending on whether PD-L1 expression was assessed in three large categories ( info:eu-repo/semantics/published |
| وصف الملف: | 2 full-text file(s): application/pdf; application/pdf |
| تدمد: | 1792-1082 1792-1074 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f03b82a12c540b5453c9bcbe4962c97 https://doi.org/10.3892/ol.2020.11458 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5f03b82a12c540b5453c9bcbe4962c97 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921082 17921074 |
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