Hypomethylation‐activated cancer‐testis gene SPANXC promotes cell metastasis in lung adenocarcinoma
| العنوان: | Hypomethylation‐activated cancer‐testis gene SPANXC promotes cell metastasis in lung adenocarcinoma |
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| المؤلفون: | Yayun Gu, Zhibin Hu, Chang Zhang, Shuaizhou Chen, Yuting Chang, Erbao Zhang, Yide Xu, Qufei Qian, Caiwang Yan, Yao Chen, Sihan Ju, Cheng Wang, Zijian Ma, Na Qin, Xuewei Wang |
| المصدر: | Journal of Cellular and Molecular Medicine |
| بيانات النشر: | John Wiley and Sons Inc., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, SPANXC, Lung Neoplasms, Cell, Mice, Nude, Adenocarcinoma of Lung, Apoptosis, Biology, medicine.disease_cause, cancer‐testis, Metastasis, 03 medical and health sciences, Mice, 0302 clinical medicine, In vivo, ROCK1, medicine, Biomarkers, Tumor, Tumor Cells, Cultured, metastasis, Animals, Humans, Promoter Regions, Genetic, Gene, Cell Proliferation, rho-Associated Kinases, Cell Biology, Original Articles, DNA Methylation, medicine.disease, lung adenocarcinoma, Prognosis, Xenograft Model Antitumor Assays, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Adenocarcinoma, Original Article, Carcinogenesis, Germ cell |
| الوصف: | Many studies have shown that there were similarity between tumorigenesis and gametogenesis. Our previous work found that cancer‐testis (CT) genes could serve as a novel source of candidate of cancer. Here, by analysing The Cancer Genome Atlas (TCGA) database, we characterized a CT gene, SPANXC, which is expressed only in testis. The SPANXC was reactivated in lung adenocarcinoma (LUAD) tissues. And the expression of SPANXC was associated with prognosis of LUAD. We also found that the activation of SPANXC was due to the promoter hypomethylation of SPANXC. Moreover, SPANXC could modulate cell metastasis both in vitro and in vivo. Mechanistically, we found that SPANXC could bind to ROCK1, a metastasis‐related gene, and thus SPANXC may regulate cell metastasis partly through interaction with ROCK1 in LUAD. Together, our results demonstrated that the CT expression pattern of SPANXC served as a crucial role in metastasis of LUAD. And these data further corroborated the resemblance between processes of germ cell development and tumorigenesis, including migration and invasion. |
| اللغة: | English |
| تدمد: | 1582-4934 1582-1838 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5f578253b4d5cb21259cc937c13008 http://europepmc.org/articles/PMC6815806 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5f5f578253b4d5cb21259cc937c13008 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15824934 15821838 |
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