Knockdown of ubiquitin-like modifier-activating enzyme 2 promotes apoptosis of clear cell renal cell carcinoma cells
| العنوان: | Knockdown of ubiquitin-like modifier-activating enzyme 2 promotes apoptosis of clear cell renal cell carcinoma cells |
|---|---|
| المؤلفون: | Xiaofeng Zou, Quanliang Liu, Guancheng Xiao, Kaiyang Qiu, Yuting Wu, Junrong Zou, Guoxi Zhang, Gengqing Wu, Rihai Xiao, Hui Xu, Biao Qian, Yunfeng Liao, Yanmin Li, Tianpeng Xie, Jinglin Shi, Zhihua He, Yuanhu Yuan |
| المصدر: | Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021) Cell Death & Disease |
| بيانات النشر: | Nature Publishing Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, Immunology, Mutant, Mice, Nude, Apoptosis, Article, Mice, Cellular and Molecular Neuroscience, Ubiquitin, In vivo, medicine, Animals, Humans, Carcinoma, Renal Cell, Oncogenesis, Cell Proliferation, Gene knockdown, biology, QH573-671, Cell growth, Chemistry, Oncogenes, Cell Biology, Middle Aged, medicine.disease, Kidney Neoplasms, In vitro, Clear cell renal cell carcinoma, Small Ubiquitin-Related Modifier Proteins, Cancer research, biology.protein, Cytology |
| الوصف: | Small ubiquitin-related modifier (SUMO) proteins are involved in the development of tumors. Ubiquitin-like modifier-activating enzyme 2 (UBA2) is an important member of the SUMO modification system; however, its role in clear cell renal cell carcinoma (ccRCC) is unclear. Therefore, we investigated the expression and function of UBA2 in ccRCC. Both mRNA and protein expression levels of UBA2 were found to be higher in ccRCC than in normal renal tissues and significantly related to the tumor size, Fuhrman grade, and tumor stage. UBA2 knockdown inhibited ccRCC cell growth, promoted apoptosis in vitro and in vivo, and decreased the abundance of a p53 mutant, c-Myc, and key enzymes of the SUMO modification system. Meanwhile, overexpression of UBA2 had the opposite effects. Overexpression of the p53 mutant or c-Myc alleviated the effects of UBA2 knockdown on ccRCC cell proliferation and apoptosis. In conclusion, targeting UBA2 may have a therapeutic potential against ccRCC. |
| اللغة: | English |
| تدمد: | 2041-4889 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601062614bb7f67750db11c3aec229ad https://doaj.org/article/ae862c9def61413fb56c973f7d4c3627 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....601062614bb7f67750db11c3aec229ad |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20414889 |
|---|