Mutant KRAS as a prognostic biomarker after hepatectomy for rectal cancer metastases: Does the primary disease site matter?
| العنوان: | Mutant KRAS as a prognostic biomarker after hepatectomy for rectal cancer metastases: Does the primary disease site matter? |
|---|---|
| المؤلفون: | Nikolaos Andreatos, Boris Galjart, Emmanouil Pikoulis, Carsten Kamphues, Richard A. Burkhart, Daisuke Morioka, Matthew J. Weiss, Per Eystein Lønning, Jaeyun Wang, Inger Marie Løes, Bashar Safar, Neda Amini, Federico NAucejo, Klaus Kaczirek, Stefan Buettner, George A. Poultsides, Kazunari Sasaki, Andrea Beer, Wolfgang L. Christopher, Georgios A. Margonis, Jinger Sun, Efstathios Antoniou, Jin He, Cornelis Verhoef, Peter Kornprat, Martin E. Kreis, Katsunori Imai, Doris Wagner, Itaru Endo, Anastasios Angelou, Hideo Baba |
| المساهمون: | Surgery |
| المصدر: | Journal of Hepato-Biliary-Pancreatic Sciences, 29(4), 417-427. Wiley-Blackwell |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, Mutant, Rectum, Primary disease, medicine.disease_cause, Proto-Oncogene Proteins p21(ras), SDG 3 - Good Health and Well-being, Internal medicine, Statistical significance, medicine, Hepatectomy, Humans, Codon, Hepatology, business.industry, Rectal Neoplasms, Hazard ratio, Liver Neoplasms, medicine.disease, Prognosis, medicine.anatomical_structure, Colonic Neoplasms, Mutation, Surgery, KRAS, business, Colorectal Neoplasms, Biomarkers |
| الوصف: | Background The prognostic implication of mutant KRAS (mKRAS) among patients with primary disease in the rectum remains unknown. Methods From 2000 to 2018, patients undergoing hepatectomy for colorectal liver metastases at 10 collaborating international institutions with documented KRAS status were surveyed. Results A total of 834 (65.8%) patients with primary colon cancer and 434 (34.2%) patients with primary rectal cancer were included. In patients with primary colon cancer, mKRAS served as a reliable prognostic biomarker of poor overall survival (OS) (hazard ratio [HR]: 1.58, 95% CI 1.28-1.95) in the multivariable analysis. Although a trend towards significance was noted, mKRAS was not found to be an independent predictor of OS in patients with primary rectal tumors (HR 1.34, 95% CI 0.98-1.80). For colon cancer, the specific codon impacted in mKRAS appears to reflect underlying disease biology and oncologic outcomes, with codon 13 being associated with particularly poor OS in patients with left-sided tumors (codon 12, HR 1.56, 95% CI 1.22-1.99; codon 13, HR 2.10 95% CI 1.43-3.08;). Stratifying the rectal patient population by codon mutation did not confer prognostic significance following hepatectomy. Conclusions While the left-sided colonic disease is frequently grouped with rectal disease, our analysis suggests that there exist fundamental biologic differences that drive disparate outcomes. Although there was a trend toward significance of KRAS mutations for patients with primary rectal cancers, it failed to achieve statistical significance. |
| تدمد: | 1868-6982 1868-6974 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602fe5d0c85c5fa43a5ac5b671679ade https://pubmed.ncbi.nlm.nih.gov/34614304 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....602fe5d0c85c5fa43a5ac5b671679ade |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18686982 18686974 |
|---|