Epithelial cell dysfunction, a major driver of asthma development
| العنوان: | Epithelial cell dysfunction, a major driver of asthma development |
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| المؤلفون: | Ian Sayers, Darryl A. Knight, Tania Maes, Irene H. Heijink, Martijn C. Nawijn, Virinchi N. S. Kuchibhotla, Mirjam P. Roffel |
| المصدر: | ALLERGY Allergy |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, HAY-FEVER, TYPE-2 INFLAMMATION, Respiratory System, RESPIRATORY SYNCYTIAL VIRUS, Disease, Review Article, Epithelium, type 2 responses, 0302 clinical medicine, immune system diseases, Medicine and Health Sciences, Immunology and Allergy, Medicine, Review Articles, Barrier function, (epi)genetics, respiratory system, medicine.anatomical_structure, type 2, THYMIC STROMAL LYMPHOPOIETIN, VIRUS, epithelial barrier, TRANSITION, GROWTH-FACTOR, Thymic stromal lymphopoietin, Immunology, Respiratory Mucosa, airway remodelling, 03 medical and health sciences, E-CADHERIN, HOUSE-DUST MITE, MESENCHYMAL, Humans, Epigenetics, RESPIRATORY SYNCYTIAL, Asthma, MESENCHYMAL TRANSITION, business.industry, Epithelial Cells, AIRWAY RESPONSIVENESS, asthma, Allergens, medicine.disease, respiratory tract diseases, 030104 developmental biology, 030228 respiratory system, BARRIER FUNCTION, responses, Respiratory epithelium, business, Airway |
| الوصف: | Airway epithelial barrier dysfunction is frequently observed in asthma and may have important implications. The physical barrier function of the airway epithelium is tightly interwoven with its immunomodulatory actions, while abnormal epithelial repair responses may contribute to remodelling of the airway wall. We propose that abnormalities in the airway epithelial barrier play a crucial role in the sensitization to allergens and pathogenesis of asthma. Many of the identified susceptibility genes for asthma are expressed in the airway epithelium, supporting the notion that events at the airway epithelial surface are critical for the development of the disease. However, the exact mechanisms by which the expression of epithelial susceptibility genes translates into a functionally altered response to environmental risk factors of asthma are still unknown. Interactions between genetic factors and epigenetic regulatory mechanisms may be crucial for asthma susceptibility. Understanding these mechanisms may lead to identification of novel targets for asthma intervention by targeting the airway epithelium. Moreover, exciting new insights have come from recent studies using single‐cell RNA sequencing (scRNA‐Seq) to study the airway epithelium in asthma. This review focuses on the role of airway epithelial barrier function in the susceptibility to develop asthma and novel insights in the modulation of epithelial cell dysfunction in asthma. |
| وصف الملف: | application/pdf |
| تدمد: | 1398-9995 0105-4538 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6046988a55b234bc7b0d118b1ea24267 https://pubmed.ncbi.nlm.nih.gov/32460363 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6046988a55b234bc7b0d118b1ea24267 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13989995 01054538 |
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