Is there penetration of titania nanoparticles in sunscreens through skin? A comparative electron and ion microscopy study
| العنوان: | Is there penetration of titania nanoparticles in sunscreens through skin? A comparative electron and ion microscopy study |
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| المؤلفون: | Tilman Butz, Maria Dolores Ynsa, János Hunyadi, J.E. Surleve-Bazeille, Philippe Moretto, Borbála Kiss, Tilo Reinert, J. Stachura, Paulo Filipe, Tamás Bíró, Wojciech Dabros, Teresa Pinheiro, Krisztián Gáspár, Etienne Gontier, João Nuno Silva |
| المصدر: | Nanotoxicology. 2:218-231 |
| بيانات النشر: | Informa UK Limited, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Materials science, Corneocyte, integumentary system, Biomedical Engineering, Analytical chemistry, Human skin, Toxicology, Rutherford backscattering spectrometry, law.invention, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, law, Transmission electron microscopy, Titanium dioxide, Stratum corneum, medicine, Electron microscope, High-resolution transmission electron microscopy |
| الوصف: | We report on a comparative study by Transmission Electron Microscopy (HRTEM) and Scanning Transmission Ion Microscopy (STIM) combined with Rutherford Backscattering Spectrometry (RBS) and Particle Induced X-Ray Emission (PIXE) on ultra-thin and thin cross-sections, respectively, of various skin samples (porcine skin, healthy human skin, human skin grafted on a severe combined immuno-deficient mouse model) to which we applied topically various formulations containing titanium dioxide (TiO2) nanoparticles with primary particle sizes in the range from 20-100 nm. Whereas the HRTEM and STIM/PIXE images reveal clear differences - mainly related to the different thickness of the cross-sections - they unambiguously show that penetration of TiO2 nanoparticles is restricted to the topmost 3-5 corneocyte layers of the stratum corneum (SC). |
| تدمد: | 1743-5404 1743-5390 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6091cae23d97bc0cbd7d1db25beda771 https://doi.org/10.1080/17435390802538508 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6091cae23d97bc0cbd7d1db25beda771 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17435404 17435390 |
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