Regulation Network of Colorectal-Cancer-Specific Enhancers in the Progression of Colorectal Cancer
| العنوان: | Regulation Network of Colorectal-Cancer-Specific Enhancers in the Progression of Colorectal Cancer |
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| المؤلفون: | Wenbin Wang, Anshun He, Bohan Chen, Jinfang Bi, Lei Zhang, Yiping Ma, Guangsong Su, Jiandang Shi, Zhongfang Zhao |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 8337, p 8337 (2021) International Journal of Molecular Sciences Volume 22 Issue 15 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Colorectal cancer, QH301-705.5, In silico, colorectal-cancer-specific enhancer, Apoptosis, Biology, HiChIP, Catalysis, Article, Epigenesis, Genetic, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, Hi-C, medicine, Biomarkers, Tumor, Tumor Cells, Cultured, Humans, Epigenetics, Physical and Theoretical Chemistry, Biology (General), Enhancer, Promoter Regions, Genetic, Molecular Biology, Gene, QD1-999, Spectroscopy, Cell Proliferation, Organic Chemistry, Cancer, General Medicine, long-range interaction, TAD, medicine.disease, Computer Science Applications, Chromatin, Gene Expression Regulation, Neoplastic, Chemistry, 030104 developmental biology, Enhancer Elements, Genetic, 030220 oncology & carcinogenesis, Mesothelin, Cancer cell, Cancer research, Disease Progression, Colorectal Neoplasms |
| الوصف: | Enhancers regulate multiple genes via higher-order chromatin structures, and they further affect cancer progression. Epigenetic changes in cancer cells activate several cancer-specific enhancers that are silenced in normal cells. These cancer-specific enhancers are potential therapeutic targets of cancer. However, the functions and regulation networks of colorectal-cancer-specific enhancers are still unknown. In this study, we profile colorectal-cancer-specific enhancers and reveal their regulation network through the analysis of HiChIP data that were derived from a colorectal cancer cell line and Hi-C and RNA-seq data that were derived from tissue samples by in silico analysis and in vitro experiments. Enhancer–promoter loops in colorectal cancer cells containing colorectal-cancer-specific enhancers are involved in more than 50% of the topological associated domains (TADs) changed in colorectal cancer cells compared to normal colon cells. In addition, colorectal-cancer-specific enhancers interact with 152 genes that are significantly and highly expressed in colorectal cancer cells. These colorectal-cancer-specific enhancer target genes include ITGB4, RECQL4, MSLN, and GDF15. We propose that the regulation network of colorectal-cancer-specific enhancers plays an important role in the progression of colorectal cancer. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1661-6596 1422-0067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e8d4836fffb6f7471cf49a782a7cce https://www.mdpi.com/1422-0067/22/15/8337 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....60e8d4836fffb6f7471cf49a782a7cce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16616596 14220067 |
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