Rhodium-NHC-catalyzed gem-specific O-selective hydropyridonation of terminal alkynes
| العنوان: | Rhodium-NHC-catalyzed gem-specific O-selective hydropyridonation of terminal alkynes |
|---|---|
| المؤلفون: | María Galiana‐Cameo, Raúl Romeo, Asier Urriolabeitia, Vincenzo Passarelli, Jesús J. Pérez‐Torrente, Victor Polo, Ricardo Castarlenas |
| المساهمون: | Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Gobierno de Aragón |
| المصدر: | Zaguán. Repositorio Digital de la Universidad de Zaragoza instname |
| بيانات النشر: | Wiley-VCH, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | General Medicine, General Chemistry, Catalysis |
| الوصف: | The dinuclear complex [Rh(μ-Cl)(η2-coe)(IPr)]2 is an efficient catalyst for the O-selective Markovnikov-type addition of 2-pyridones to terminal alkynes. DFT calculations support a hydride-free pathway entailing intramolecular oxidative protonation of a π-alkyne by a κ1N-hydroxypyridine ligand. Subsequent O-nucleophilic attack on a metallacyclopropene species affords an O-alkenyl-2-oxypyridine chelate rhodium intermediate as the catalyst resting state. The release of the alkenyl ether is calculated as the rate-determining step. Financial support from the Spanish Ministerio de Ciencia e Innovación MCIN/AEI/10.13039/501100011033, under the Projects PID2019-103965GB-I00 and PGC2018-099383-B-I00, and the Departamento de Ciencia, Universidad y Sociedad del Conocimiento del Gobierno de Aragón (group E42_20R) is gratefully acknowledged. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60eaafecc92dc8121310fb80e5a46b76 http://hdl.handle.net/10261/284676 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....60eaafecc92dc8121310fb80e5a46b76 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |