Age‐specific 3‐year cumulative risk of cervical cancer and high‐grade dysplasia on biopsy in 9434 women who underwent HPV cytology cotesting
| العنوان: | Age‐specific 3‐year cumulative risk of cervical cancer and high‐grade dysplasia on biopsy in 9434 women who underwent HPV cytology cotesting |
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| المؤلفون: | Eric Luna, Jiaqiong Xu, Yimin Ge, Donna Armylagos, Jim Hsu, Mary R. Schwartz, Dina R. Mody, Paul A. Christensen, Haijun Zhou |
| المصدر: | Cancer Cytopathology. 127:757-764 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Cancer Research, medicine.medical_specialty, Databases, Factual, Uterine Cervical Neoplasms, 030209 endocrinology & metabolism, Risk Assessment, Sensitivity and Specificity, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Cytology, Biopsy, medicine, Humans, Human papillomavirus, Papillomaviridae, Early Detection of Cancer, Retrospective Studies, Cervical cancer, Chi-Square Distribution, medicine.diagnostic_test, High grade dysplasia, business.industry, Obstetrics, Incidence, Biopsy, Needle, Papillomavirus Infections, Age Factors, Prognosis, medicine.disease, Immunohistochemistry, female genital diseases and pregnancy complications, Cumulative risk, Squamous intraepithelial lesion, Oncology, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Age stratification, Female, business, Papanicolaou Test |
| الوصف: | BACKGROUND High-risk human papillomavirus (HPV)-Papanicolaou (Pap) cotesting is recommended for cervical cancer screening in women aged ≥30 years. The current study analyzed the effectiveness of cotesting on risk management in different age groups. METHODS A retrospective review of a 5-year cytology database identified 9434 women with HPV-Pap cotesting and follow-up cervical biopsy. The 3-year cumulative risk of developing high-grade cervical lesions (≥high-grade squamous intraepithelial lesion [HSIL]) was analyzed using age stratification. RESULTS The 3-year cumulative risk of developing ≥HSIL was found to be significantly different in women with baseline cotesting HPV-positive and Pap-positive results (HPV+/Pap+; defined as ≥atypical squamous cells of undetermined significance), HPV+ and Pap-negative results, and HPV-negative and Pap+ results at 19.2%, 7.9%, and 3.1%, respectively (P |
| تدمد: | 1934-6638 1934-662X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613b7fc014b63a73113eae05e8f28f17 https://doi.org/10.1002/cncy.22192 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....613b7fc014b63a73113eae05e8f28f17 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19346638 1934662X |
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