Triclabendazole Treatment Failure forFasciola hepaticaInfection among Preschool and School-Age Children, Cusco, Peru1
| العنوان: | Triclabendazole Treatment Failure forFasciola hepaticaInfection among Preschool and School-Age Children, Cusco, Peru1 |
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| المؤلفون: | Ruben Bascope, Miguel M. Cabada, Melinda B. Tanabe, A. Clinton White, Martha Lopez, Maria Luisa Morales |
| المصدر: | Emerging Infectious Diseases |
| بيانات النشر: | Centers for Disease Control and Prevention (CDC), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Epidemiology, efficacy, school-age children, Drug resistance, Treatment failure, trematode, Feces, 0302 clinical medicine, Peru, Treatment Failure, 030212 general & internal medicine, Child, Anthelmintics, liver fluke, Schools, School age child, Fasciola, biology, Liver fluke, Cusco, Infectious Diseases, Triclabendazole, Child, Preschool, Female, medicine.drug, Microbiology (medical), Fascioliasis, medicine.medical_specialty, preschool children, Adolescent, 030231 tropical medicine, parasites, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, Fasciola hepatica, antimicrobial resistance, Retrospective Studies, drug resistance, business.industry, Research, Retrospective cohort study, biology.organism_classification, Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, Peru, infection, business |
| الوصف: | We conducted a retrospective cohort study of children who had chronic fascioliasis in the highlands of Peru to determine triclabendazole treatment efficacy. Children passing Fasciola eggs in stool were offered directly observed triclabendazole treatment (>1 doses of 10 mg/kg). Parasitologic cure was evaluated by using microscopy of stool 1–4 months after each treatment. A total of 146 children who had chronic fascioliasis participated in the study; 53% were female, and the mean ± SD age was 10.4 ± 3.1 years. After the first treatment, 55% of the children achieved parasitologic cure. Cure rates decreased after the second (38%), third (30%), and fourth (23%) treatments; 17 children (11.6%) did not achieve cure after 4 treatments. Higher baseline egg counts and lower socioeconomic status were associated with triclabendazole treatment failure. Decreased triclabendazole efficacy in disease-endemic communities threatens control efforts. Further research on triclabendazole resistance and new drugs to overcome it are urgently needed. |
| تدمد: | 1080-6059 1080-6040 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61510d93d2af15ef619f23b854c70231 https://doi.org/10.3201/eid2707.203900 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....61510d93d2af15ef619f23b854c70231 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10806059 10806040 |
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