Routes of Allergic Sensitization and Myeloid Cell IKK beta Differentially Regulate Antibody Responses and Allergic Airway Inflammation in Male and Female Mice
| العنوان: | Routes of Allergic Sensitization and Myeloid Cell IKK beta Differentially Regulate Antibody Responses and Allergic Airway Inflammation in Male and Female Mice |
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| المؤلفون: | Estelle Cormet-Boyaka, Michael J. Fial, Ian C. Davis, Stephanie DiBartola, Junbae Jee, Astrid Bonnegarde-Bernard, Haley Steiner, Daniel Tomé, Prosper N. Boyaka |
| المساهمون: | Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Ohio State University [Columbus] (OSU), Institut National de la Recherche Agronomique (INRA)-AgroParisTech |
| المصدر: | PLoS ONE PLoS ONE, Public Library of Science, 2014, 9 (3), pp.e92307. ⟨10.1371/journal.pone.0092307⟩ PLoS ONE, Vol 9, Iss 3, p e92307 (2014) |
| بيانات النشر: | HAL CCSD, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Allergy, Myeloid, Pulmonology, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Respiratory System, lcsh:Medicine, Administration, Oral, medicine.disease_cause, Allergic sensitization, Mice, 0302 clinical medicine, Allergen, Molecular Cell Biology, Allergies, Medicine and Health Sciences, Medicine, Myeloid Cells, lcsh:Science, Immune Response, 0303 health sciences, Multidisciplinary, biology, Reverse Transcriptase Polymerase Chain Reaction, Drug Administration Routes, Animal Models, respiratory system, 3. Good health, I-kappa B Kinase, medicine.anatomical_structure, Cytokines, Female, medicine.symptom, Anatomy, Cellular Types, Injections, Intraperitoneal, Research Article, Cholera Toxin, Histology, Ovalbumin, Intraperitoneal injection, Immunology, Blotting, Western, Inflammation, Mouse Models, Research and Analysis Methods, Real-Time Polymerase Chain Reaction, Allergic inflammation, 03 medical and health sciences, Model Organisms, Animals, RNA, Messenger, 030304 developmental biology, business.industry, lcsh:R, Biology and Life Sciences, Cell Biology, Allergens, medicine.disease, Asthma, respiratory tract diseases, Mice, Inbred C57BL, Immune System, Antibody Formation, biology.protein, lcsh:Q, Clinical Immunology, business, 030215 immunology |
| الوصف: | WOS:000333675600031; International audience; Gender influences the incidence and/or the severity of several diseases and evidence suggests a higher rate of allergy and asthma among women. Most experimental models of allergy use mice sensitized via the parenteral route despite the fact that the mucosal tissues of the gastrointestinal and respiratory tracts are major sites of allergic sensitization and/or allergic responses. We analyzed allergen-specific Ab responses in mice sensitized either by gavage or intraperitoneal injection of ovalbumin together with cholera toxin as adjuvant, as well as allergic inflammation and lung functions following subsequent nasal challenge with the allergen. Female mice sensitized intraperitoneally exhibited higher levels of serum IgE than their male counterparts. After nasal allergen challenge, these female mice expressed higher Th2 responses and associated inflammation in the lung than males. On the other hand, male and female mice sensitized orally developed the same levels of allergen-specific Ab responses and similar levels of lung inflammation after allergen challenge. Interestingly, the difference in allergen-specific Ab responses between male and female mice sensitized by the intraperitoneal route was abolished in IKK beta(Delta Mye) mice, which lack IKK beta in myeloid cells. In summary, the oral or systemic route of allergic sensitization and IKK beta signaling in myeloid cells regulate how the gender influences allergen-specific responses and lung allergic inflammation. |
| اللغة: | English |
| تدمد: | 0003-3367 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61611d4811b20aea424a18bcb2ad5af9 https://hal-agroparistech.archives-ouvertes.fr/hal-01568631 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....61611d4811b20aea424a18bcb2ad5af9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00033367 19326203 |
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