Effect of rosmarinic acid on differentiation and mineralization of MC3T3-E1 osteoblastic cells on titanium surface
| العنوان: | Effect of rosmarinic acid on differentiation and mineralization of MC3T3-E1 osteoblastic cells on titanium surface |
|---|---|
| المؤلفون: | Do-Seon Lim, Cheol Park, Soon-Jeong Jeong, Moon-Jin Jeong, Sung Ok Kim, Yung Hyun Choi |
| المصدر: | Animal Cells and Systems, Vol 25, Iss 1, Pp 46-55 (2021) Animal Cells and Systems article-version (VoR) Version of Record |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | musculoskeletal diseases, 0301 basic medicine, rosmarinic acid, Biocompatibility, chemistry.chemical_element, General Biochemistry, Genetics and Molecular Biology, Osseointegration, 03 medical and health sciences, chemistry.chemical_compound, mc3t3-e1 osteoblasts, 0302 clinical medicine, stomatognathic system, mineralization, titanium, lcsh:QH301-705.5, lcsh:R5-920, Rosmarinic acid, osseointegration, virus diseases, Biomaterial, differentiation, Mineralization (soil science), Mc3t3 e1, stomatognathic diseases, 030104 developmental biology, lcsh:Biology (General), chemistry, Chemical engineering, 030220 oncology & carcinogenesis, Animal Science and Zoology, Titanium surface, lcsh:Medicine (General), Developmental Biology, Research Article, Titanium |
| الوصف: | Titanium (Ti) is a widely used biomaterial for dental implants because of its outstanding biocompatibility for hard tissues. Osseointegration, the interaction between implanted biomaterials and living cells in bone, is essential for successful implantation. Rosmarinic acid (RA) is a plant-derived phytochemical with low toxicity and side effects and has various effects that can be applied as a therapeutic substance. The MC3T3-E1 osteoblastic cells on the Ti surface in medium with or without 14 μg/ml RA were used to test RA effects on osteoblast differentiation, cell viability and mineralization during differentiation. RA treatment increased osteoblast differentiation, cell viability and mineralization in MC3T3-E1 osteoblastic cells on Ti surface during differentiation, upregulating Runx-2 and OPG, but downregulating RANKL. This study suggest that RA should be applied as an effective functional and therapeutic substance to enhance osseointegration of osteoblast cells by increasing differentiation, mineralization, and bone formation through the RANKL/RANK/OPG pathway during the differentiation in MC3T3-E1 osteoblastic cells on the Ti surface. |
| تدمد: | 2151-2485 1976-8354 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a3d33a91cec7ee770c6caad1af12f2 https://doi.org/10.1080/19768354.2021.1886987 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....61a3d33a91cec7ee770c6caad1af12f2 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 21512485 19768354 |
|---|