Progesterone receptor modulators in breast cancer
| العنوان: | Progesterone receptor modulators in breast cancer |
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| المؤلفون: | Ronald D. WIEHLE, |
| المصدر: | Volume: 38, Issue: 6 772-785 Turkish Journal of Biology |
| بيانات النشر: | The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Progesterone receptor,PRMs,antiprogestins,mammary carcinogenesis,biomarkers, medicine.medical_specialty, Fulvestrant, biology, Physiology, Anastrozole, Cell Biology, medicine.disease, Microbiology, Estrogen Receptor Antagonists, Breast cancer, Endocrinology, Internal medicine, Progesterone receptor, Genetics, Cancer research, medicine, biology.protein, Aromatase, skin and connective tissue diseases, General Agricultural and Biological Sciences, Molecular Biology, Tamoxifen, medicine.drug, Telapristone Acetate |
| الوصف: | Breast cancer has been treated successfully with selective estrogen receptor antagonists (SERMs) such as tamoxifen, receptor-depleting agents such as fulvestrant, and aromatase inhibitors such as anastrozole. Selective progesterone receptor modulators (SPRMs or PRMs) have not been studied as much and are currently under investigation for inhibition of mammary carcinogenesis in animal models and breast cancer prevention trials in women. They might follow tamoxifen and aromatase inhibitors in the adjuvant treatment of breast cancers with acquired resistance. These uses have not provoked ground-breaking progress or studies and PRMs do not have a high profile. Most in vitro and in vivo studies indicate that PRMs preferentially suppress cell proliferation and also induce apoptosis. In this review we summarized the data on the effects of PRMs and particularly of the antiprogestins RU-486 (mifepristone) and CDB-4124 (Progenta, Proellex or telapristone acetate) on breast cancer models. Both agents have been employed in preclinical and clinical studies for prevention and treatment of breast cancer. This author believes that PRMs should be investigated more intensely. |
| وصف الملف: | application/pdf |
| تدمد: | 1303-6092 1300-0152 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b6f5c6a853f972be09d38a9facfe38 https://doi.org/10.3906/biy-1407-44 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....61b6f5c6a853f972be09d38a9facfe38 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13036092 13000152 |
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