Changes in the profile and therapeutic care of people who use drugs with HCV mono-infection: a retrospective study between 2015 and 2019 from a monocentric tertiary referent center in France
| العنوان: | Changes in the profile and therapeutic care of people who use drugs with HCV mono-infection: a retrospective study between 2015 and 2019 from a monocentric tertiary referent center in France |
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| المؤلفون: | Dominique Paya, Aurélie Velay-Rusch, François Habersetzer, Robert Bader, Martine Tebacher, Frédéric Chaffraix, Michel Doffoel, Simona Tripon, Thomas Baumert, Lucile Haumesser, Nicolas Meyer, Anais Lang, Florence Ernwein, Jean-Philippe Lang, Maude Royant |
| المساهمون: | Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immuno-Rhumatologie Moléculaire, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | European Journal of Gastroenterology & Hepatology European Journal of Gastroenterology & Hepatology, 2022, 34 (5), pp.560-566. ⟨10.1097/MEG.0000000000002307⟩ |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Sustained Virologic Response, Hepatology, business.industry, Gastroenterology, Retrospective cohort study, Hepacivirus, Sciences du Vivant [q-bio]/Médecine humaine et pathologie, Hepatitis C, Chronic, Referent, Antiviral Agents, Fibrosis, Hepatitis C, Pharmaceutical Preparations, Family medicine, medicine, Humans, Center (algebra and category theory), business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Retrospective Studies |
| الوصف: | People who use drugs (PWUDs) are the main group at risk for hepatitis C virus (HCV) transmission and a key population for hepatitis C elimination. Multidisciplinary team (MDT) meetings were set up in France in December 2014 within regional reference centers to supervise the prescriptions and delivery of direct-acting antivirals (DAAs) to optimize the management of HCV infection. The aim of this retrospective study was to analyze the changes in the profile and therapeutic care of PWUDs with HCV mono-infection according to the evolution of MDT meetings in a regional tertiary reference center.Between 2015 and 2019, overall 1912 HCV-infected patients presented at the MDT meetings, 547 were PWUDs with HCV mono-infection treated with DAAs. Five periods were defined according to the evolution of MDT meetings. The profile and management of PWUDs were compared among these five periods.Over time, the frequency of advanced stage of fibrosis decreased from 90.8 to 36.3% (P 0.001), whereas the therapeutic care of the patients in primary addictology centers and networks of general practitioners increased from 17.4 to 55% (P 0.001). The frequency of excessive alcohol consumption varied between 9.1 and 30% (P = 0.003) and that of opioid substitution therapy between 42.5 and 70% (P 0.001). The Sustained virologic response assessed 12 weeks after the end of treatment rate was above 95% for the five periods.Between 2015 and 2019, the changes in the profile and management of PWUDs have followed the evolution of MDT meetings concerning patients with less advanced fibrosis and more therapeutic hepatitis C care made by the primary care centers. |
| تدمد: | 0954-691X 1473-5687 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c3778a706393dbb63cd3d699beb70c https://doi.org/10.1097/meg.0000000000002307 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....61c3778a706393dbb63cd3d699beb70c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0954691X 14735687 |
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