HIV-Specific CD8+ T-Cell Immunity in Humanized Bone Marrow–Liver–Thymus Mice
| العنوان: | HIV-Specific CD8+ T-Cell Immunity in Humanized Bone Marrow–Liver–Thymus Mice |
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| المؤلفون: | Timothy Dudek, Todd M. Allen |
| المصدر: | The Journal of Infectious Diseases. 208:S150-S154 |
| بيانات النشر: | Oxford University Press (OUP), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Recent Advances in Humanized Mice: Accelerating the Development of an HIV Vaccine, T cell, HIV Infections, Mice, SCID, CD8-Positive T-Lymphocytes, Biology, medicine.disease_cause, Mice, Immune system, Acquired immunodeficiency syndrome (AIDS), Immunity, medicine, Animals, Humans, Immunology and Allergy, Cytotoxic T cell, HIV vaccine, Simian immunodeficiency virus, medicine.disease, Virology, Disease Models, Animal, Infectious Diseases, medicine.anatomical_structure, Humanized mouse, Immunology, HIV-1 |
| الوصف: | CD8(+) T-cell responses play a critical role in the control of human immunodeficiency virus (HIV) infection, and recent vaccine studies in nonhuman primates now demonstrate the ability of T cells to prevent the early dissemination of simian immunodeficiency virus and perhaps clear residual infection. Recent advances in humanized mouse models, in particular the humanized bone marrow-liver-thymus (BLT) mouse model, show promise in their ability not only to support sustained infection with HIV, but also to recapitulate human HIV-specific immunity. The availability of a small-animal model with which to study human-specific immune responses to HIV would greatly facilitate the elucidation of mechanisms of immune control, as well as accelerate the iterative testing of promising vaccine candidates. Here we discuss data from our recent study detailing the composition and efficacy of HIV-specific CD8(+) T-cell responses in humanized BLT mice that was recently presented at a Harvard Center for AIDS Research symposium on humanized mouse models for HIV vaccine design. |
| تدمد: | 1537-6613 0022-1899 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ca658be847fc2c2ca31b50cd00cfc7 https://doi.org/10.1093/infdis/jit320 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....61ca658be847fc2c2ca31b50cd00cfc7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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