Pregnancy environment, and not preconception, leads to fetal growth restriction and congenital abnormalities associated with diabetes
| العنوان: | Pregnancy environment, and not preconception, leads to fetal growth restriction and congenital abnormalities associated with diabetes |
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| المؤلفون: | Monika A. Ward, Jonathan M. Riel, Pai-Jong Stacy Tsai, Yasuhiro Yamauchi |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_treatment, Embryonic Development, lcsh:Medicine, 030209 endocrinology & metabolism, Oogenesis, Article, Congenital Abnormalities, Andrology, Diabetes Complications, 03 medical and health sciences, Mice, 0302 clinical medicine, Medical research, Pregnancy, Diabetes mellitus, Developmental biology, medicine, Diabetes Mellitus, Animals, Humans, Blastocyst, lcsh:Science, Fetus, Multidisciplinary, In vitro fertilisation, Fetal Growth Retardation, business.industry, Incidence, lcsh:R, medicine.disease, Embryo Transfer, Embryo transfer, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Phenotype, Maternal Exposure, Prenatal Exposure Delayed Effects, embryonic structures, Gestation, Female, lcsh:Q, Disease Susceptibility, business |
| الوصف: | Maternal diabetes can lead to pregnancy complications and impaired fetal development. The goal of this study was to use a mouse model of reciprocal embryo transfer to distinguish between the preconception and gestational effects of diabetes. To induce diabetes female mice were injected with a single high dose of streptozotocin and 3 weeks thereafter used as oocyte donors for in vitro fertilization (IVF) and as recipients for embryo transfer. Following IVF embryos were cultured to the blastocyst stage in vitro or transferred to diabetic and non-diabetic recipients. Diabetic and non-diabetic females did not differ in regard to the number of oocytes obtained after ovarian stimulation, oocytes ability to become fertilized, and embryo development in vitro. However, diabetic females displayed impaired responsiveness to superovulation. Reciprocal embryo transfer resulted in similar incidence of live fetuses and abortions, and no changes in placental size. However, fetuses carried by diabetic recipients were smaller compared to those carried by non-diabetic recipients, regardless hyperglycemia status of oocyte donors. Congenital abnormalities were observed only among the fetuses carried by diabetic recipients. The findings support that the diabetic status during pregnancy, and not the preconception effect of diabetes on oogenesis, leads to fetal growth restriction and congenital deformities. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61dd4f4162e4a36f35b93275ba28a558 http://link.springer.com/article/10.1038/s41598-020-69247-w |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....61dd4f4162e4a36f35b93275ba28a558 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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