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Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients

التفاصيل البيبلوغرافية
العنوان: Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients
المؤلفون: Pierre Peterlin, Camille Debord, Marion Eveillard, Alice Garnier, Amandine Le Bourgeois, Thierry Guillaume, Maxime Jullien, Marie C. Béné, Patrice Chevallier
المصدر: Journal of Cellular and Molecular Medicine. 26:5486-5492
بيانات النشر: Wiley, 2022.
سنة النشر: 2022
مصطلحات موضوعية: Adult, Leukemia, Myeloid, Acute, Humans, Molecular Medicine, Myeloid Cells, Prospective Studies, Cell Biology, Neoplasm Recurrence, Local, Monocytes
الوصف: Myeloid Derived Suppressive Cells (MDSC) are capable to suppress innate and adaptive immune responses, thus favouring solid cancer progression. However, little is known about the role of MDSC in acute myeloid leukaemia (AML). In this monocentric prospective study, 73 adult AML patients, eligible for first-line intensive chemotherapy, were included with the aim to study the influence on long-term outcomes of peripheral blood (PB) levels of monocytic (M) MDSC (M-MDSC) assessed by flow cytometry. A percentage of peripheral M-MDSC higher than 0.55% of leukocytes at diagnosis and a decrease of M-MDSC% after induction came out both as independent negative prognostic factors for leukaemia-free and overall survival.
تدمد: 1582-4934
1582-1838
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62232747a39eaebbcda3cce1a55ab716
https://doi.org/10.1111/jcmm.17576
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....62232747a39eaebbcda3cce1a55ab716
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15824934
15821838