Erratum: Polge, C., et al. UBE2E1 Is Preferentially Expressed in the Cytoplasm of Slow-Twitch Fibers and Protects Skeletal Muscles from Exacerbated Atrophy upon Dexamethasone Treatment. Cells 2018, 7, 214
| العنوان: | Erratum: Polge, C., et al. UBE2E1 Is Preferentially Expressed in the Cytoplasm of Slow-Twitch Fibers and Protects Skeletal Muscles from Exacerbated Atrophy upon Dexamethasone Treatment. Cells 2018, 7, 214 |
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| المؤلفون: | Cécile Polge, Lydie Combaret, Cécile Coudy-Gandilhon, Christiane Deval, Daniel Béchet, Clara Tournebize, Didier Attaix, Agnès Claustre, Julien Aniort, Marco Sandri, Andrea Armani, Daniel Taillandier |
| المصدر: | Cells, Vol 7, Iss 12, p 242 (2018) Cells |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, UBE2E1, E3 ubiquitin ligases, Article, 03 medical and health sciences, myosin heavy chain, Atrophy, atrophy, Internal medicine, medicine, skeletal muscle, lcsh:QH301-705.5, Dexamethasone, Chemistry, E2 ubiquitin-conjugating enzymes, General Medicine, medicine.disease, MuRF1, 030104 developmental biology, Endocrinology, n/a, lcsh:Biology (General), Cytoplasm, Erratum, ubiquitin-proteasome system, actin, medicine.drug |
| الوصف: | Skeletal muscle mass is reduced during many diseases or physiological situations (disuse, aging), which results in decreased strength and increased mortality. Muscle mass is mainly controlled by the ubiquitin-proteasome system (UPS), involving hundreds of ubiquitinating enzymes (E2s and E3s) that target their dedicated substrates for subsequent degradation. We recently demonstrated that MuRF1, an E3 ubiquitin ligase known to bind to sarcomeric proteins (telethonin, α-actin, myosins) during catabolic situations, interacts with 5 different E2 enzymes and that these E2-MuRF1 couples are able to target telethonin, a small sarcomeric protein, for degradation. Amongst the E2s interacting with MuRF1, E2E1 was peculiar as the presence of the substrate was necessary for optimal MuRF1-E2E1 interaction. In this work, we focused on the putative role of E2E1 during skeletal muscle atrophy. We found that E2E1 expression was restricted to type I and type IIA muscle fibers and was not detectable in type IIB fibers. This strongly suggests that E2E1 targets are fiber-specific and may be strongly linked to the contractile and metabolic properties of the skeletal muscle. However, E2E1 knockdown was not sufficient for preserving the protein content in C2C12 myotubes subjected to a catabolic state (dexamethasone treatment), suggesting that E2E1 is not involved in the development of muscle atrophy. By contrast, E2E1 knockdown aggravated the atrophying process in both catabolic C2C12 myotubes and the Tibialis anterior muscle of mice, suggesting that E2E1 has a protective effect on muscle mass. |
| اللغة: | English |
| تدمد: | 2073-4409 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62351f8c2cb7f5e17e6465fd77891f26 https://www.mdpi.com/2073-4409/7/12/242 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....62351f8c2cb7f5e17e6465fd77891f26 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
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