Associations between Blood Lead Levels and Coronary Artery Stenosis Measured Using Coronary Computed Tomography Angiography
| العنوان: | Associations between Blood Lead Levels and Coronary Artery Stenosis Measured Using Coronary Computed Tomography Angiography |
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| المؤلفون: | Won-Ju Park, Yeongjae Yoo, WonYang Kang, Byung Chan Lee, Dae-Young Lim, Seunghyeon Cho, Jai-Dong Moon, Suwhan Kim, Ryoung Jin Park |
| المصدر: | Environmental Health Perspectives |
| بيانات النشر: | Environmental Health Perspectives, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Computed Tomography Angiography, Health, Toxicology and Mutagenesis, Coronary stenosis, Disease, 010501 environmental sciences, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Medicine, 030212 general & internal medicine, Risk factor, Lead (electronics), Normal range, 0105 earth and related environmental sciences, business.industry, Research, Angiography, Coronary Stenosis, Public Health, Environmental and Occupational Health, Coronary computed tomography angiography, Blood pressure, Lead, Lead exposure, Cardiology, Female, Tomography, X-Ray Computed, business |
| الوصف: | Background: Lead exposure is a risk factor for increased blood pressure and cardiovascular disease, even when blood lead levels (BLLs) are within the normal range. Objective: This study aimed to investigate the association between BLL and coronary artery stenosis (CAS) in asymptomatic adults using 128-slice dual-source coronary computed tomography (CT) angiography. Methods: We analyzed medical records data from 2,193 adults (1,461 men and 732 women) who elected to complete a screening health examination, coronary CT angiography, and BLL measurement during 2011–2018 and had no history of CAS symptoms, cardiovascular disease, or occupational exposure to lead. Logistic regression models were used to estimate associations between moderate-to-severe CAS (≥25% stenosis) and a 1-μg/dL increase in blood lead, with and without adjustment for age, sex, hypertension, diabetes mellitus, dyslipidemia, body mass index, regular exercise, smoking status, and alcohol drinking. Results: BLLs ranged from 0.12 to 10.14μg/dL, with an arithmetic mean of 2.71±1.26μg/dL. The arithmetic mean was higher for men than for women (2.98±1.26μg/dL vs. 2.18±1.08μg/dL, p |
| تدمد: | 1552-9924 0091-6765 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623531a1a3bf86faeab5df5aab66204b https://doi.org/10.1289/ehp7351 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....623531a1a3bf86faeab5df5aab66204b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15529924 00916765 |
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