A longitudinal study of brain anatomy changes preceding dementia in Down syndrome
| العنوان: | A longitudinal study of brain anatomy changes preceding dementia in Down syndrome |
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| المؤلفون: | Joan Deus, Gerard Martínez-Vilavella, Jesús Pujol, Javier García-Alba, Susanna Esteba-Castillo, Núria Ribas-Vidal, Laura Blanco-Hinojo, Raquel Fenoll, Ramon Novell |
| المصدر: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid NeuroImage : Clinical NeuroImage: Clinical, Vol 18, Iss, Pp 160-166 (2018) |
| بيانات النشر: | Elsevier BV, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Aging, Down syndrome, Longitudinal study, medicine.medical_specialty, Cognitive Neuroscience, Hippocampus, Neuropsychological Tests, lcsh:Computer applications to medicine. Medical informatics, lcsh:RC346-429, Cognitive aging, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Genetic model, medicine, Humans, Dementia, Radiology, Nuclear Medicine and imaging, Longitudinal Studies, skin and connective tissue diseases, lcsh:Neurology. Diseases of the nervous system, Temporal cortex, business.industry, Substantia innominata, Brain, Regular Article, Cognition, Middle Aged, Alzheimer's, medicine.disease, Magnetic Resonance Imaging, 030104 developmental biology, Brain aging, Neurology, Disease Progression, lcsh:R858-859.7, Female, sense organs, Neurology (clinical), Down Syndrome, business, 030217 neurology & neurosurgery |
| الوصف: | We longitudinally assessed Down syndrome individuals at the age of risk of developing dementia to measure changes in brain anatomy and their relationship to cognitive impairment progression.Forty-two Down syndrome individuals were initially included, of whom 27 (mean age 46.8 years) were evaluable on the basis of completing the 2-year follow-up and success in obtaining good quality MRI exams. Voxel-based morphometry was used to estimate regional brain volumes at baseline and follow-up on 3D anatomical images. Longitudinal volume changes for the group and their relationship with change in general cognitive status and specific cognitive domains were mapped.As a group, significant volume reduction was identified in the substantia innominata region of the basal forebrain, hippocampus, lateral temporal cortex and left arcuate fasciculus. Volume reduction in the substantia innominata and hippocampus was more prominent in individuals whose clinical status changed from cognitively stable to mild cognitive impairment or dementia during the follow-up. Relevantly, longitudinal memory score change was specifically associated with volume change in the hippocampus, prospective memory with prefrontal lobe and verbal comprehension with language-related brain areas.Results are notably concordant with the well-established anatomical changes signaling the progression to dementia in Alzheimer's disease, despite the dense baseline pathology that developmentally accumulates in Down syndrome. This commonality supports the potential value of Down syndrome as a genetic model of Alzheimer's neurodegeneration and may serve to further support the view that Down syndrome patients are best candidates to benefit from treatment research in Alzheimer's disease.•Longitudinal changes in brain anatomy were identified in Down syndrome individuals.•Basal forebrain and hippocampal volume reductions paralleled clinical progression.•The overall anatomical pattern identified resembled Alzheimer's neurodegeneration. |
| وصف الملف: | application/pdf |
| تدمد: | 2213-1582 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625e2906a423a7be6581bf1be797d6c2 https://doi.org/10.1016/j.nicl.2018.01.024 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....625e2906a423a7be6581bf1be797d6c2 |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 22131582 |
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