Outcome of unrelated donor stem cell transplantation for children with severe aplastic anemia
| العنوان: | Outcome of unrelated donor stem cell transplantation for children with severe aplastic anemia |
|---|---|
| المؤلفون: | Thomas J. Gross, Jeffery M. Lipton, Naynesh Kamani, Mary Eapen, John P. Klein, Anne Woolfrey, Evelio Perez-Albuerne, K. Scott Baker |
| المصدر: | British Journal of Haematology. 141:216-223 |
| بيانات النشر: | Wiley, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Transplantation Conditioning, Adolescent, Neutrophils, Anemia, medicine.medical_treatment, Graft vs Host Disease, Histocompatibility Testing, Hematopoietic stem cell transplantation, Article, Leukocyte Count, HLA Antigens, Internal medicine, Humans, Medicine, Aplastic anemia, Child, business.industry, Hematopoietic Stem Cell Transplantation, Bone marrow failure, Anemia, Aplastic, Hematology, medicine.disease, Survival Analysis, Tissue Donors, Surgery, Transplantation, surgical procedures, operative, Treatment Outcome, medicine.anatomical_structure, Child, Preschool, Acute Disease, Chronic Disease, Bone marrow, business |
| الوصف: | For children with severe aplastic anemia (SAA) who fail immunosuppressive therapy and lack a human leucocyte antigen (HLA)-matched sibling donor, unrelated donors provide a source of hematopoietic stem cells. Data from 195 children with acquired SAA who underwent unrelated donor transplantation between 1989 and 2003 were analyzed. Neutrophil recovery (86% at day-28) was higher with total body irradiation-containing conditioning regimen and in younger recipients (agedor =16 years) receiving grafts from older donors (aged40 years). Recovery was lower after mismatched transplants and transplantations prior to 1997. Mortality rates were higher after mismatched transplants, in recipients with a poor performance score, and when the interval between diagnosis and transplantation was longer than 4 years. When restricted to donor-recipient pairs with allele-level HLA typing (8-loci; n = 118), mortality rates were also higher after mismatched transplants and older recipients receiving grafts from older donors; 5-year probabilities of overall survival after HLA-A, -B, -C, -DRB1 matched and mismatched transplants adjusted for donor and recipient age were 57% and 39%, respectively (P = 0.008). The data suggest that unrelated donor transplantation is an acceptable alternative for children; early referral for transplantation and identification of an HLA-matched (allele-level) donor offers the best outcome. |
| تدمد: | 1365-2141 0007-1048 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626812fe7f5c91b3861ae669e8874fa1 https://doi.org/10.1111/j.1365-2141.2008.07030.x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....626812fe7f5c91b3861ae669e8874fa1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652141 00071048 |
|---|