Reduction in Severe Hypoglycemia With Long-Term Continuous Subcutaneous Insulin Infusion in Type I Diabetes
| العنوان: | Reduction in Severe Hypoglycemia With Long-Term Continuous Subcutaneous Insulin Infusion in Type I Diabetes |
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| المؤلفون: | R. D. Steed, Paul C. Davidson, Bruce W. Bode |
| المصدر: | Diabetes Care. 19:324-327 |
| بيانات النشر: | American Diabetes Association, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Adult, Male, Pediatrics, medicine.medical_specialty, Time Factors, Diabetic ketoacidosis, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Population, Hypoglycemia, Diabetic Ketoacidosis, Insulin Infusion Systems, Diabetes mellitus, Internal Medicine, medicine, Humans, Insulin, Adverse effect, education, Glycemic, Glycated Hemoglobin, Advanced and Specialized Nursing, education.field_of_study, Cross-Over Studies, business.industry, Blood Glucose Self-Monitoring, Incidence, Patient Selection, Incidence (epidemiology), medicine.disease, Surgery, Diabetes Mellitus, Type 1, Female, business, Algorithms, Follow-Up Studies |
| الوصف: | OBJECTIVE To compare the incidence of severe hypoglycemia in patients crossed over from multiple daily injections (MDIs) of insulin to continuous subcutaneous insulin infusion (CSII). RESEARCH DESIGN AND METHODS From a population of 255 patients using CSII, all patients who met the following selection criteria were included in the present study: 1) a minimum of 12 months on intensive therapy with MDIs before switching to CSII, and 2) a minimum of 12 months on CSII after crossover. Glycemic control and adverse event rates for the 1-year MDI control period were compared with those for the CSII therapy period. RESULTS The incidence of severe hypoglycemia during MDI therapy declined from 138 to 22 events per 100 patient-years during the 1st year of CSII (P < 0.0001) and remained significantly lower in years 2, 3, and 4 on CSII (26, 39, and 36, respectively). HbA1c levels did not change significantly between the MDI phase and any year on CSII. However, in the subgroup of patients who had pre-CSII HbA1c levels of ≥8.0%, the change to CSII was associated with a significant reduction in HbA1c from baseline to year 1 (8.9 ± 0.8 vs. 8.1 ± 1.0%, P = 0.0004). The difference in diabetic ketoacidosis rates between the MDI year (14.6 events per 100 patientyears) and the CSII period (7.2 events per 100 patient-years) was not statistically significant. CONCLUSIONS CSII therapy was associated with a marked and sustained reduction in the rate of severe hypoglycemia without adversely affecting the level of glycemic control attained during MDI therapy. The more reproducible and flexible insulin delivery afforded by CSII was considered to be the major factor contributing to the improvement in severe hypoglycemia rates. |
| تدمد: | 1935-5548 0149-5992 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ef053f47ccaee3ac358a4e05018ac9 https://doi.org/10.2337/diacare.19.4.324 |
| رقم الأكسشن: | edsair.doi.dedup.....62ef053f47ccaee3ac358a4e05018ac9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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