Deciphering the mechanism of action of antitubercular compounds with metabolomics
| العنوان: | Deciphering the mechanism of action of antitubercular compounds with metabolomics |
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| المؤلفون: | Raúl G. Barletta, Isin T. Sakallioglu, Robert Powers, Patrick H. Dussault |
| المصدر: | Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 4284-4299 (2021) Computational and Structural Biotechnology Journal |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Screening techniques, Biophysics, Computational biology, Review, Biochemistry, Multi-drug resistant tuberculosis, Metabolomics, Structural Biology, Mechanisms of action, Genetics, medicine, Tuberculosis, ComputingMethodologies_COMPUTERGRAPHICS, Drug discovery, business.industry, Multi-drug-resistant tuberculosis, Pharmacometabolomics, medicine.disease, Computer Science Applications, Mechanism of action, Antitubercular drugs, medicine.symptom, business, TP248.13-248.65, Biotechnology |
| الوصف: | Graphical abstract Tuberculosis (TB), one of the oldest and deadliest bacterial diseases, continues to cause serious global economic, health, and social problems. Current TB treatments are lengthy, expensive, and routinely ineffective against emerging drug resistant strains. Thus, there is an urgent need for the identification and development of novel TB drugs possessing comprehensive and specific mechanisms of action (MoAs). Metabolomics is a valuable approach to elucidating the MoA, toxicity, and potency of promising chemical leads, which is a critical step of the drug discovery process. Recent advances in metabolomics methodologies for deciphering MoAs include high-throughput screening techniques, the integration of multiple omics methods, mass spectrometry imaging, and software for automated analysis. This review describes recently introduced metabolomics methodologies and techniques for drug discovery, highlighting specific applications to the discovery of new antitubercular drugs and the elucidation of their MoAs. |
| اللغة: | English |
| تدمد: | 2001-0370 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630819662f91abed34ed7c39ae0d3fb3 http://www.sciencedirect.com/science/article/pii/S200103702100324X |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....630819662f91abed34ed7c39ae0d3fb3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20010370 |
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