Maternal antibodies inhibit neonatal and infant responses to vaccination by shaping the early-life B cell repertoire within germinal centers
| العنوان: | Maternal antibodies inhibit neonatal and infant responses to vaccination by shaping the early-life B cell repertoire within germinal centers |
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| المؤلفون: | Christiane S. Eberhardt, Paul-Henri Lambert, Maria Vono, Sylvain Lemeille, Dennis Christensen, Beatris Mastelic-Gavillet, Claire-Anne Siegrist, Floriane Auderset, Peter Andersen |
| المصدر: | Cell Reports, Vol. 28, No 7 (2019) pp. 1773-1784.e5 Vono, M, Eberhardt, C S, Auderset, F, Mastelic-Gavillet, B, Lemeille, S, Christensen, D, Andersen, P, Lambert, P H & Siegrist, C A 2019, ' Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers ', Cell Reports, vol. 28, no. 7, pp. 1773-1784.e5 . https://doi.org/10.1016/j.celrep.2019.07.047 Cell Reports, Vol 28, Iss 7, Pp 1773-1784.e5 (2019) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Antibody Formation/immunology, T-Lymphocytes, ddc:616.07, Antibodies, Viral, Inbred C57BL, Mice, 0302 clinical medicine, Orthomyxoviridae Infections/immunology/virology, Pregnancy, germinal centers, Gene expression, Maternal-Fetal Exchange, lcsh:QH301-705.5, Inbred BALB C, B-Lymphocytes, Mice, Inbred BALB C, Orthomyxoviridae/immunology, biology, Helper-Inducer/immunology, Vaccination, repertoire, B-Lymphocytes/immunology, T-Lymphocytes, Helper-Inducer, Orthomyxoviridae, 3. Good health, Antibodies/blood/immunology, epitope masking, medicine.anatomical_structure, Female, Antibody, Offspring, General Biochemistry, Genetics and Molecular Biology, Antibodies, 03 medical and health sciences, Germinal Center/immunology, Orthomyxoviridae Infections, medicine, Animals, Gene, B cell, Germinal center, Maternal-Fetal Exchange/immunology, Germinal Center, Newborn, neonates, Mice, Inbred C57BL, 030104 developmental biology, maternal antibodies, Immunoglobulin class switching, Immunization, Animals, Newborn, lcsh:Biology (General), Immunology, Antibody Formation, biology.protein, Viral/blood/immunology, 030217 neurology & neurosurgery |
| الوصف: | Summary: Maternal antibodies (MatAbs) protect offspring from infections but limit their responses to vaccination. The mechanisms of this inhibition are still debated. Using murine early-life immunization models mimicking the condition prevailing in humans, we observed the induction of CD4-T, T follicular helper, and germinal center (GC) B cell responses even when early-life antibody responses were abrogated by MatAbs. GC B cells induced in the presence of MatAbs form GC structures and exhibit canonical GC changes in gene expression but fail to differentiate into plasma cells and/or memory B cells in a MatAb titer-dependent manner. Furthermore, GC B cells elicited in the presence or absence of MatAbs use different VH and Vk genes and show differences in genes associated with B cell differentiation and isotype switching. Thus, MatAbs do not prevent B cell activation but control the output of the GC reaction both quantitatively and qualitatively, shaping the antigen-specific B cell repertoire. : Maternal antibodies (MatAbs) protect offspring from infections but limit their vaccine responses through still poorly known mechanisms. Vono et al. report that MatAbs do not prevent B cell activation or germinal center formation but control plasma cell and memory B cell differentiation, shaping the long-term antigen-specific B cell repertoire. Keywords: immunization, maternal antibodies, neonates, repertoire, germinal centers, epitope masking |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2211-1247 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634bcd4fc3dafb5374f8c4aa9c1a163c https://archive-ouverte.unige.ch/unige:143451 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....634bcd4fc3dafb5374f8c4aa9c1a163c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22111247 |
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