Physiologic Determinants of Exercise Capacity in Pulmonary Langerhans Cell Histiocytosis: A Multidimensional Analysis
| العنوان: | Physiologic Determinants of Exercise Capacity in Pulmonary Langerhans Cell Histiocytosis: A Multidimensional Analysis |
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| المؤلفون: | Bernard Aguilaniu, Olivier Le Rouzic, Camille Rolland-Debord, Jonathan Giovannelli, Geraldine François, Abdellatif Tazi, Benoit Wallaert, Stéphanie Fry, Cécile Chenivesse, Alain Delobbe, Stéphane Dominique, Agnès Bellocq, Nicolas Bricout, Carole Langlois |
| المساهمون: | Service de Pneumologie, Immunologie et Allergologie [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de Pneumologie et Réanimation Médicale [CHU Pitié-Salpêtrière] (Département ' R3S '), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Neurophysiologie Respiratoire Expérimentale et Clinique, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service pharmaceutique, CHU de Lille, Service de biostatistiques [CHU Lille], Service de Radiologie (LILLE - Radio), Faculté de médecine [Université Joseph-Fourrier], Université Joseph-Fourrier, Service d’Explorations Fonctionnelles de la Respiration, de l’Exercice et de la Dyspnée [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Rouen, Normandie Université (NU), Hôpital de la Citadelle, CHU Amiens-Picardie, Centre de référence des Histiocytoses, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Biostatistiques [CHRU Lille], Service d'Explorations Fonctionnelles de la Respiration, de l’Exercice et de la Dyspnée [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
| المصدر: | PLoS ONE PLoS ONE, Public Library of Science, 2017, 12 (1), pp.e0170035. ⟨10.1371/journal.pone.0170035⟩ PLoS ONE, 2017, 12 (1), pp.e0170035. ⟨10.1371/journal.pone.0170035⟩ PLoS ONE, Vol 12, Iss 1, p e0170035 (2017) |
| بيانات النشر: | Public Library of Science, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Pulmonology, Anaerobic Threshold, lcsh:Medicine, Hyperpnea, 030204 cardiovascular system & hematology, Pulmonary function testing, Diagnostic Radiology, 0302 clinical medicine, Mathematical and Statistical Techniques, DLCO, Animal Cells, Ultrasound Imaging, Medicine and Health Sciences, Public and Occupational Health, lcsh:Science, Tomography, Principal Component Analysis, Multidisciplinary, Pulmonary Hypertension, Exercise Tolerance, Radiology and Imaging, Middle Aged, Sports Science, Respiratory Function Tests, Chemistry, Echocardiography, Physical Sciences, Cardiology, Female, medicine.symptom, Cellular Types, Anaerobic exercise, Statistics (Mathematics), Research Article, Chemical Elements, Adult, medicine.medical_specialty, Imaging Techniques, Immune Cells, Immunology, Antigen-Presenting Cells, Neuroimaging, Air trapping, Research and Analysis Methods, 03 medical and health sciences, FEV1/FVC ratio, Diagnostic Medicine, Internal medicine, medicine, Humans, Sports and Exercise Medicine, Statistical Methods, Exercise, Aerobic capacity, business.industry, lcsh:R, Biology and Life Sciences, Physical Activity, Cell Biology, Dendritic Cells, medicine.disease, Computed Axial Tomography, Oxygen, Histiocytosis, Langerhans-Cell, Dyspnea, 030228 respiratory system, Physical Fitness, Langerhans Cells, Multivariate Analysis, Physical therapy, lcsh:Q, Ventilatory threshold, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Mathematics, Neuroscience |
| الوصف: | International audience; BackgroundReduced exercise capacity severely impacts quality of life in pulmonary Langerhans cell histiocytosis. Ascertaining mechanisms that impair exercise capacity is necessary to identify targets for symptomatic treatments.MethodsDyspnea, pulmonary function tests and cardiopulmonary exercise test were analysed in 62 study participants. Data were compared between subjects with impaired and normal aerobic capacity (V’O2 peak less than 84% versus 84% predicted or more). Data were reduced using a principal component analysis. Multivariate analysis included V’O2 peak as the dependent variable and principal components as covariates.ResultsV’O2 peak was reduced in 44 subjects (71%). Subjects with impaired aerobic capacity presented: (i) decreased FEV1, FVC, FEV1/FVC, DLCO and DLCO/VA and increased AaDO2, (ii) increased ventilatory equivalents at ventilatory threshold, VD/VT peak, AaDO2 peak and PaCO2 peak and decreased ventilatory reserve and PaO2 peak. There was no difference between groups in dyspnea scores. Principal component analysis extracted 4 principal components interpreted as follows: PC1: gas exchange; PC2: “pseudorestriction”; PC3: exercise-induced hyperpnea; PC4: air trapping. Multivariate analysis explained 65% of V’O2 peak. The 4 principal components were independently associated with V’O2 peak (βcoefficients: PC1: 9.3 [4.6; 14], PC2: 7.5 [3; 11.9], PC3: -5.3 [-9.6;-1.], PC4: -9.8 [-14,9;-4.7]).ConclusionImpaired exercise capacity is frequent in pulmonary Langerhans cell histiocytosis. It is mainly caused by pulmonary changes but is not associated with increased dyspnea intensity. Therefore, treating the lung represents a relevant approach for improving exercise capacity, even in patients experiencing mild dyspnea. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6351512f12c2255591070670234526f4 http://europepmc.org/articles/PMC5225005 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6351512f12c2255591070670234526f4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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