mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
| العنوان: | mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors |
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| المؤلفون: | Ping Jun Zhu, Jacqunae Mays, Loredana Stoica, Chien-Ju Chen, Mauro Costa-Mattioli |
| المصدر: | Nature neuroscience |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, rictor, animal structures, Regulator, Hippocampus, Mechanistic Target of Rapamycin Complex 2, mTORC1, Mechanistic Target of Rapamycin Complex 1, Hippocampal formation, Receptors, Metabotropic Glutamate, mTORC2, Article, memory, mTOR complexes, Mice, 03 medical and health sciences, 0302 clinical medicine, mental disorders, Animals, Learning, long-term depression, Mice, Knockout, Sirolimus, synaptic plasticity, Behavior, Animal, Long-Term Synaptic Depression, musculoskeletal, neural, and ocular physiology, General Neuroscience, Glutamate receptor, Recognition, Psychology, Regulatory-Associated Protein of mTOR, Electrophysiological Phenomena, nervous system diseases, Mice, Inbred C57BL, 030104 developmental biology, Metabotropic receptor, nervous system, raptor, Metabotropic glutamate receptor, Space Perception, Female, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD). Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD and associated behaviors. Moreover, rapamycin blocks mGluR-LTD in mTORC1-deficient mice. Interestingly, both rapamycin and mGluR activation regulate mTOR complex 2 (mTORC2) activity, and mTORC2-deficient mice show impaired mGluR-LTD and associated behaviors. Thus, mTORC2 is a major regulator of mGluR-LTD. |
| تدمد: | 1546-1726 1097-6256 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63556736ef6fe8234b2fc3b604ab2a47 https://doi.org/10.1038/s41593-018-0156-7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....63556736ef6fe8234b2fc3b604ab2a47 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15461726 10976256 |
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