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High-Resolution Manometry Thresholds and Motor Patterns Among Asymptomatic individuals

التفاصيل البيبلوغرافية
العنوان: High-Resolution Manometry Thresholds and Motor Patterns Among Asymptomatic individuals
المؤلفون: Albis Hani, José María Remes-Troche, Salvatore Tolone, C. Prakash Gyawali, Edoardo Savarino, Julio Perez de la Serna, Daniel Sifrim, Daniel Cisternas, Jordi Serra, Rosa I. Ramos, Sabine Roman, Dustin A. Carlson, Osamu Kawamura, Arvind Rengarajan, Jamal Hayat, Sutep Gonlachanvit, Shobna Bhatia, Ans Pauwels, Ana Maria Leguizamo, Zhiqin Wong, Serhat Bor, Luiz J. Abrahao, John E. Pandolfino, Yeong Yeh Lee, Benjamin D. Rogers
المصدر: Clinical Gastroenterology and Hepatology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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بيانات النشر: Elsevier Science Inc, 2022.
سنة النشر: 2022
مصطلحات موضوعية: Adult, Male, High-Resolution Manometry, medicine.medical_specialty, Percentile, Supine position, Adolescent, Manometry, Achalasia, Distal Latency, Asymptomatic, Integrated Relaxation Pressure, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Internal medicine, medicine, Humans, Esophageal Motility Disorders, Esophagogastric junction, High resolution manometry, Distal Contractile Integral, Aged, Distal latency, Hepatology, business.industry, Gastroenterology, Study Position, Middle Aged, medicine.disease, Esophageal Achalasia, 030220 oncology & carcinogenesis, Cardiology, 030211 gastroenterology & hepatology, Female, Esophagogastric Junction, medicine.symptom, business, Chicago Classification
الوصف: OBJECTIVE: High-resolution manometry (HRM) is the current standard for characterization of esophageal body and esophagogastric junction (EGJ) function. We aimed to examine the prevalence of abnormal esophageal motor patterns in health, and to determine optimal thresholds for software metrics across HRM systems. DESIGN: Manometry studies from asymptomatic adults were solicited from motility centers worldwide, and were manually analyzed using integrated relaxation pressure (IRP), distal latency (DL), and distal contractile integral (DCI) in standardized fashion. Normative thresholds were assessed using fifth and/or 95th percentile values. Chicago Classification v3.0 criteria were applied to determine motor patterns across HRM systems, study positions (upright vs supine), ages, and genders. RESULTS: Of 469 unique HRM studies (median age 28.0, range 18-79 years). 74.6% had a normal HRM pattern; none had achalasia. Ineffective esophageal motility (IEM) was the most frequent motor pattern identified (15.1% overall), followed by EGJ outflow obstruction (5.3%). Proportions with IEM were lower using stringent criteria (10.0%), especially in supine studies (7.1%-8.5%). Other motor patterns were rare (0.2%-4.1% overall) and did not vary by age or gender. DL thresholds were close to current norms across HRM systems, while IRP thresholds varied by HRM system and study position. Both fifth and 95th percentile DCI values were lower than current thresholds, both in upright and supine positions. CONCLUSIONS: Motor abnormalities are infrequent in healthy individuals and consist mainly of IEM, proportions of which are lower when using stringent criteria in the supine position. Thresholds for HRM metrics vary by HRM system and study position.
اللغة: English
تدمد: 1542-3565
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63613cad77e3308e829aa656d47b7c3d
https://hdl.handle.net/11454/76458
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....63613cad77e3308e829aa656d47b7c3d
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15423565