Psoriasis Regression Analysis of MHC Loci Identifies Shared Genetic Variants with Vitiligo
| العنوان: | Psoriasis Regression Analysis of MHC Loci Identifies Shared Genetic Variants with Vitiligo |
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| المؤلفون: | Zai Xing Wang, Xianyong Yin, Xing Fan, You Wen Zhou, Yong Mei Lv, Zheng Zhang, Sen Yang, Su Min He, Da Yan Hu, Feng Yu Zhang, Liangdan Sun, Xuejun Zhang, Kun Ju Zhu, Xian Bo Zuo, Yang Li, Hui Cheng |
| المصدر: | PLoS ONE, Vol 6, Iss 11, p e23089 (2011) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, Linkage disequilibrium, Anatomy and Physiology, lcsh:Medicine, Autoimmunity, Genome-wide association study, Vitiligo, HLA Antigens, lcsh:Science, Pigmentary Disorders, Skin, Genetics, Multidisciplinary, Genomics, Middle Aged, Regression Analysis, Medicine, Chromosomes, Human, Pair 6, Female, Research Article, Adult, Adolescent, Inflammatory Diseases, Immunology, Locus (genetics), Single-nucleotide polymorphism, HLA-C Antigens, Dermatology, Human leukocyte antigen, Biology, Major histocompatibility complex, Polymorphism, Single Nucleotide, Microbiology, Autoimmune Diseases, Young Adult, HLA-DQ Antigens, Psoriasis, medicine, Humans, Genetic Predisposition to Disease, Inflammation, lcsh:R, Immunity, medicine.disease, HLA-B Antigens, Immune System, Genetics of Disease, biology.protein, Clinical Immunology, lcsh:Q |
| الوصف: | Psoriasis is a common inflammatory skin disease with genetic components of both immune system and the epidermis. PSOR1 locus (6q21) has been strongly associated with psoriasis; however, it is difficult to identify additional independent association due to strong linkage disequilibrium in the MHC region. We performed stepwise regression analyses of more than 3,000 SNPs in the MHC region genotyped using Human 610-Quad (Illumina) in 1,139 cases with psoriasis and 1,132 controls of Han Chinese population to search for additional independent association. With four regression models obtained, two SNPs rs9468925 in HLA-C/HLA-B and rs2858881 in HLA-DQA2 were repeatedly selected in all models, suggesting that multiple loci outside PSOR1 locus were associated with psoriasis. More importantly we find that rs9468925 in HLA-C/HLA-B is associated with both psoriasis and vitiligo, providing first important evidence that two major skin diseases share a common genetic locus in the MHC, and a basis for elucidating the molecular mechanism of skin disorders. |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636f3b31e0b864adc45f54749be2fa0e https://doi.org/10.1371/journal.pone.0023089 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....636f3b31e0b864adc45f54749be2fa0e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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