How Atypical Penile Curvature Influence Clinical Outcomes in Patients with Peyronie’s Disease Receiving Collagenase Clostridium Histolyticum Therapy?
| العنوان: | How Atypical Penile Curvature Influence Clinical Outcomes in Patients with Peyronie’s Disease Receiving Collagenase Clostridium Histolyticum Therapy? |
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| المؤلفون: | Andrea Cocci, Andrea Mari, Giorgio Ivan Russo, Nicola Mondaini, Marina Di Mauro, Fabrizio Di Maida, Riccardo Campi, Marco Falcone, Gianmartin Cito, Giovanni Cacciamani, Francesco Sessa, Andrea Minervini |
| المصدر: | The World Journal of Men's Health, Vol 38, Iss 1, Pp 78-84 (2020) |
| بيانات النشر: | Korean Society for Sexual Medicine and Andrology, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Aging, medicine.medical_specialty, intralesional injections, Peyronie's disease, Urology, Urinary system, 030232 urology & nephrology, lcsh:Medicine, lcsh:RC870-923, 03 medical and health sciences, 0302 clinical medicine, Collagenase clostridium histolyticum, Interquartile range, therapeutics, Medicine, Pharmacology (medical), In patient, Collagenases, Intralesional injections, Penile induration, Therapeutics, 030219 obstetrics & reproductive medicine, business.industry, Health Policy, lcsh:R, Public Health, Environmental and Occupational Health, Odds ratio, medicine.disease, penile induration, lcsh:Diseases of the genitourinary system. Urology, Psychiatry and Mental health, medicine.anatomical_structure, Reproductive Medicine, peyronie’s disease, collagenases, Penile curvature, business, Penis, medicine.drug |
| الوصف: | Purpose: The aim of this study was to evaluate the efficacy of collagenase Clostridium histolyticum (CCH) in patients with Peyronie’s disease (PD) suffering from atypical deformities. Materials and Methods: We retrospectively collected data of patients with atypical penile curvature (PC) secondary to PD. All patients underwent a modified treatment protocol, consisting of 3 intralesional injections of 0.9 mg of CCH performed at 4-week intervals at the point of maximum PC. Patients were instructed to follow a strict routine, involving daily modeling of erect penis and stretching at the urinary toilette time, two minutes each. Success was defined as a decrease in PC of ≥20° from baseline. Results: Sixty-five patients were included in the analysis. Median age was 59.0 years (interquartile range [IQR], 53.0 to 63.0 years), median curvature 40.0° (IQR, 30.0° to 45.0°) median duration of the disease 12.0 years (IQR, 6.5 to 24.0 years). Fiftythree patients (81.54%) had ventral PC, 7 (10.77%) hourglass PC, and 5 (7.69%) shortening PC. Median changes of PC were -20.0 (IQR, -20.0 to -10.0; p |
| اللغة: | English |
| تدمد: | 2287-4690 2287-4208 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63750625f4e1fed4340c00c2606c646a https://doaj.org/article/39187517670c4bc7b61c2082414948c7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....63750625f4e1fed4340c00c2606c646a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22874690 22874208 |
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