Performance of point-of-care international normalized ratio measurement to diagnose trauma-induced coagulopathy
| العنوان: | Performance of point-of-care international normalized ratio measurement to diagnose trauma-induced coagulopathy |
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| المؤلفون: | Pierre Albaladejo, Julien Brun, Jean-Luc Bosson, Jean-François Payen, Yvonnick Boué, Thomas Mistral, Pauline Manhes, Jules Greze, Pierre Bouzat |
| المصدر: | Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Vol 25, Iss 1, Pp 1-7 (2017) |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, endocrine system, medicine.medical_specialty, Point-of-Care Systems, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, 03 medical and health sciences, 0302 clinical medicine, Trauma Centers, health services administration, Coagulation testing, Coagulopathy, Humans, Medicine, heterocyclic compounds, International Normalized Ratio, Prospective Studies, cardiovascular diseases, Prospective cohort study, Original Research, Blood coagulation test, Point of care, business.industry, fungi, Trauma center, lcsh:Medical emergencies. Critical care. Intensive care. First aid, 030208 emergency & critical care medicine, lcsh:RC86-88.9, Blood Coagulation Disorders, Middle Aged, medicine.disease, Surgery, Hospitalization, Emergency Medicine, Wounds and Injuries, Female, Blood Coagulation Tests, France, Nuclear medicine, business, Kappa, Trauma induced coagulopathy |
| الوصف: | Trauma-induced coagulopathy (TIC) is a common feature after severe trauma. Detection of TIC is based upon classic coagulation tests including international normalized ratio (INR) value. Point-of-care (POC) devices have been developed to rapidly measure INR at the bedside on whole blood. The aim of the study was to test the precision of the Coagucheck® XS Pro device for INR measurement at hospital admission after severe trauma. We conducted a prospective observational study in a French level I trauma center. From January 2015 to May 2016, 98 patients with a suspicion of a post-traumatic acute hemorrhage had POC-INR measurement on whole blood concomitantly to classic laboratory INR determination (lab-INR) on plasma at hospital admission. The agreement between the two methods in sorting three predefined categories of INR (normal coagulation, moderate TIC and severe TIC) was evaluated using the Cohen’s kappa test with a quadratic weighting. The correlation between POC-INR and lab-INR was measured using the Pearson’s coefficient. We also performed a Bland and Altman analysis. The agreement between the lab-INR and the POC-INR was moderate (Kappa = 0.45 [95% CI 0.36–0.50]) and the correlation between the two measurements was also weak (Pearson’s coefficient = 0.44 [95% CI 0.27–0.59]). Using a Bland and Altman analysis, the mean difference (bias) for INR was 0.22 [95% CI 0.02–0.42], and the standard deviation (precision) of the difference was 1.01. POC Coagucheck® XS Pro device is not reliable to measure bedside INR. Its moderate agreement with lab-INR weakens the usefulness of such device after severe trauma. NCT02869737 . Registered 9 August 2016. |
| تدمد: | 1757-7241 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6379c9c2146069ea3cb2b50b1dac3c4c https://doi.org/10.1186/s13049-017-0404-y |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6379c9c2146069ea3cb2b50b1dac3c4c |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 17577241 |
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