Efficacy and safety of lithium and lamotrigine for the maintenance treatment of clinically stable patients with bipolar disorder: A systematic review and meta‐analysis of double‐blind, randomized, placebo‐controlled trials with an enrichment design
| العنوان: | Efficacy and safety of lithium and lamotrigine for the maintenance treatment of clinically stable patients with bipolar disorder: A systematic review and meta‐analysis of double‐blind, randomized, placebo‐controlled trials with an enrichment design |
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| المؤلفون: | Yasuhiko Hashimoto, Kazuo Mishima, Kenji Sakuma, Masakazu Hatano, Satoru Esumi, Masaki Kato, Ikuo Nomura, Yuki Matsuda, Norio Watanabe, Makoto Okuya, Nobumi Miyake, Nakao Iwata, Taro Kishi, Yuki Matsui, Kazuto Oya, Ryota Hashimoto |
| المصدر: | Neuropsychopharmacology Reports |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Lithium (medication), Micro Reports, Lithium, Lamotrigine, Cochrane Library, Placebo, Micro Report, Double-Blind Method, systematic review, Recurrence, Internal medicine, Humans, Medicine, Pharmacology (medical), Bipolar disorder, Randomized Controlled Trials as Topic, bipolar disorder, Pharmacology, Depression, business.industry, Middle Aged, medicine.disease, Discontinuation, Psychiatry and Mental health, Clinical Psychology, meta‐analysis, Meta-analysis, Relative risk, Female, business, Antipsychotic Agents, medicine.drug |
| الوصف: | Aim Whether patients with adult bipolar disorder (BD) who have been clinically stabilized with lithium or lamotrigine should continue this medication is not established fully. This systematic review and meta‐analysis evaluated the efficacy and safety of lithium and lamotrigine for maintenance treatment in clinically stable patients with adult BD. Methods This meta‐analysis included only double‐blind, randomized, placebo‐controlled trials with an enrichment design that selected patients who responded acutely to lithium or lamotrigine. Reports prior to November 15, 2018, were retrieved from the PubMed/Cochrane Library/Embase. The primary outcome was the relapse rate due to any mood episode at the study endpoint. Other outcomes were relapse rates due to a manic/hypomanic/mixed episode or depression at the study endpoint, discontinuation rate, death, and death by suicide. Risk ratios (RRs) (95% confidence intervals) were calculated. When the random‐effects model showed significant differences between groups, the number‐needed‐to‐treat (NNT) was estimated. Results The search retrieved two studies regarding lithium (N = 218) and four evaluating lamotrigine (N = 706). Both drugs were superior to placebo for reducing the relapse rate due to any mood episode [lithium: RR = 0.52 (0.41‐0.66), P Study, patient, and treatment characteristics of the included double‐blinded, randomized placebo‐controlled trials of patients with bipolar disorder |
| تدمد: | 2574-173X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6400db50e491f67e28ddfb84f30cd4d5 https://doi.org/10.1002/npr2.12056 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6400db50e491f67e28ddfb84f30cd4d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2574173X |
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