Prediction of progression of chronic atrophic gastritis with Helicobacter pylori and poor prognosis of gastric cancer by CYP3A4
| العنوان: | Prediction of progression of chronic atrophic gastritis with Helicobacter pylori and poor prognosis of gastric cancer by CYP3A4 |
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| المؤلفون: | Baohong Gu, Ruiliang Su, Furong Wang, Shaojun Tang, Jike Hu, Fan Zhang, Hao Chen, Cong Chen, Tianyu Wang, Xuemei Li, Yumin Li |
| المصدر: | Journal of Gastroenterology and Hepatology. 35:425-432 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Gastritis, Atrophic, Male, Risk, medicine.medical_specialty, Atrophic gastritis, Gene Expression, Chronic gastritis, medicine.disease_cause, Gastroenterology, Helicobacter Infections, Stomach Neoplasms, Internal medicine, Gene expression, Cytochrome P-450 CYP3A, Humans, Medicine, Helicobacter pylori, Hepatology, biology, business.industry, Stomach, Cancer, Prognosis, medicine.disease, biology.organism_classification, Cell Transformation, Neoplastic, medicine.anatomical_structure, Chronic Disease, Disease Progression, Immunohistochemistry, Female, business, Carcinogenesis, Forecasting |
| الوصف: | BACKGROUND AND AIM It has been well documented that Helicobacter pylori (H. pylori) infection is a risk factor for aggravating gastric mucosal atrophy. However, the exact molecular mechanism mediating this process is not fully elucidated. The purpose of this study was to identify biomarkers, which may predict the risk for progression of chronic atrophic gastritis (CAG) with H. pylori. METHODS GSE27411 was downloaded from the Gene Expression Omnibus. The differentially expressed genes (DEGs) between H. pylori-infected samples without CAG and H. pylori-infected CAG samples were analyzed. Gene Ontology and pathway enrichment analyses were performed, followed by protein-protein interaction network construction. We used immunohistochemistry analysis to identify DEGs in 20 chronic gastritis, 20 CAG, and 22 gastric cancer (GC) specimens. RESULTS A total of 303 upregulated and 26 downregulated DEGs were identified. The pathways enriched by upregulated DEGs were mainly related to fat digestion and absorption, peroxisome proliferator-activated receptor signaling pathway, and chemical carcinogenesis. Cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) had the highest degrees in protein-protein interaction network. Moreover, the positive rates of CYP3A4 protein expression in chronic gastritis, CAG, and GC were 10% (2/20), 55% (11/20), and 77.3% (17/22), respectively (P |
| تدمد: | 1440-1746 0815-9319 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6401b082eab99383474bb11bcba04ec7 https://doi.org/10.1111/jgh.14844 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....6401b082eab99383474bb11bcba04ec7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14401746 08159319 |
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