Electrocardiographic and Hemodynamic Effects of Intravenous Infusion of Bupivacaine, Ropivacaine, Levobupivacaine, and Lidocaine In Anesthetized Ewes
| العنوان: | Electrocardiographic and Hemodynamic Effects of Intravenous Infusion of Bupivacaine, Ropivacaine, Levobupivacaine, and Lidocaine In Anesthetized Ewes |
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| المؤلفون: | David Bec, Jean-Yves Bansard, Patrick Guinet, Pascal Lecorre, Eric Wodey, Jean-Pierre Estebe, Maja Ratajczak-Enselme, François Chevanne, Claude Ecoffey |
| المساهمون: | Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'anesthésie réanimation chirurgicale [Rennes], Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou, Laboratoire de Pharmacie Galenique, Biopharmacie et Pharmacie Clinique, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Senhadji, Lotfi, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Hôpital Pontchaillou, Laboratoire de Pharmacie Galenique, Biopharmacie et Pharmacie Clinique [Rennes], Université de Rennes (UR) |
| المصدر: | Regional Anesthesia and Pain Medicine Regional Anesthesia and Pain Medicine, Lippincott, Williams & Wilkins, 2009, 34 (1), pp.17-23. ⟨10.1097/AAP.0b013e31819338e2⟩ Regional Anesthesia and Pain Medicine, 2009, 34 (1), pp.17-23. ⟨10.1097/AAP.0b013e31819338e2⟩ |
| بيانات النشر: | BMJ, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Tachycardia, Time Factors, Lidocaine, MESH: Myocardial Contraction, Blood Pressure, Ventricular tachycardia, Electrocardiography, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Heart Rate, 030202 anesthesiology, Cluster Analysis, Ropivacaine, MESH: Animals, Anesthetics, Local, MESH: Heart Rate, Infusions, Intravenous, Levobupivacaine, Principal Component Analysis, MESH: Anesthesia, General, MESH: Blood Pressure, General Medicine, Bupivacaine, MESH: Amides, 3. Good health, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Anesthesia, MESH: Bupivacaine, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, medicine.symptom, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, medicine.drug, MESH: Hemodynamics, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, MESH: Sheep, Anesthesia, General, MESH: Anesthetics, Local, QT interval, 03 medical and health sciences, QRS complex, medicine, Animals, cardiovascular diseases, MESH: Infusions, Intravenous, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, [SDV.IB] Life Sciences [q-bio]/Bioengineering, MESH: Principal Component Analysis, Models, Statistical, Sheep, business.industry, MESH: Time Factors, Hemodynamics, medicine.disease, Amides, Myocardial Contraction, MESH: Cluster Analysis, MESH: Electrocardiography, MESH: Lidocaine, Anesthesiology and Pain Medicine, Tachycardia, Ventricular, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, MESH: Tachycardia, Ventricular, business, MESH: Female, MESH: Models, Statistical, 030217 neurology & neurosurgery |
| الوصف: | International audience; BACKGROUND AND OBJECTIVES: Neural blockade techniques are associated with a risk of acute cardiac toxicity after accidental intravenous (IV) injection of local anesthetics. The aim of this study was to compare electrocardiographic (ECG) and hemodynamic (HEM) effects induced by IV infusion of local anesthetics in an anesthetized ewe model. METHODS: Thirty-two anesthetized ewes received IV bupivacaine (BUPI), ropivacaine (ROPI), or levobupivacaine (S-BUPI) at an equimolar dose, or lidocaine (LIDO) at a 3-fold higher rate (n = 8 in each group). RR, PR, QRS, and QT intervals (QTc), changes (Delta) in systolic and diastolic arterial pressure (SAP and DAP), and in myocardial contractility (dP/dt), were assessed every 30 seconds for 7 minutes. From main ECG variables (RR, PR, QRS, QT), we proposed to use multiple correspondence analysis and hierarchical ascending classification to explore the structure of statistical dependencies among those measurements, and to determine the different patterns of ECG and HEM changes induced by infusion of BUPI, ROPI, S-BUPI, and LIDO. RESULTS: Graphic representation of multiple correspondence analysis associated BUPI with the most pronounced modifications in ECG and HEM variables, followed by in decreasing order ROPI, S-BUPI, and LIDO. Comparisons of clusters identified by hierarchical ascending classification confirmed this classification for ECG variables. Ventricular tachycardia occurred only in the BUPI group. CONCLUSIONS: In our anesthetized ewe model, high dose IV infusion of BUPI induced the most marked changes in RR, PR, QRS, QT, QTc intervals, DeltaSAP, and DeltadP/dt. ROPI altered ECG variables less than BUPI but more than S-BUPI. LIDO was associated with the smallest changes. |
| وصف الملف: | application/pdf |
| تدمد: | 1098-7339 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64057bb218d2a6cba15bd1faf151acb3 https://doi.org/10.1097/aap.0b013e31819338e2 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....64057bb218d2a6cba15bd1faf151acb3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10987339 |
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