Malawian children with chest-indrawing pneumonia with and without comorbidities or danger signs
| العنوان: | Malawian children with chest-indrawing pneumonia with and without comorbidities or danger signs |
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| المؤلفون: | Melda Phiri, Jun Hwang, Tisungane Mvalo, Amy Sarah Ginsburg, Daphne Gadama, Claightone Chirombo, Susanne May, Madalitso Maliwichi |
| المصدر: | Journal of Global Health |
| بيانات النشر: | International Society of Global Health, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pediatrics, medicine.medical_specialty, Anemia, 030231 tropical medicine, Severe Acute Malnutrition, HIV Infections, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Child, business.industry, Health Policy, Public Health, Environmental and Occupational Health, Amoxicillin, Infant, Articles, Pneumonia, medicine.disease, Clinical trial, business, Malaria, medicine.drug, Cohort study |
| الوصف: | Background Children with comorbidities or danger signs are often excluded from trials evaluating pneumonia treatment. Methods We sought to investigate whether the percentage of children with chest-indrawing pneumonia cured at Day 14 was lower among those with HIV infection or exposure, malaria, moderate or severe acute malnutrition, or anemia enrolled in a prospective observational cohort study than among children without these comorbidities enrolled in a concurrent prospective randomized controlled trial evaluating duration of amoxicillin treatment in Lilongwe, Malawi. Results Children with chest-indrawing pneumonia and comorbidities but without danger signs did not have statistically significant higher treatment failure rates by Day 6 than those in the chest-indrawing pneumonia clinical trial. However, children with chest-indrawing pneumonia and HIV infection or exposure, malaria, or moderate or severe acute malnutrition had higher rates of not being clinically cured at Day 14 when compared to children without these comorbidities (adjusted differences ranging from 7.7% to 17.0%). Furthermore, among children without danger signs at enrollment, but with HIV infection or HIV exposure or moderate or severe acute malnutrition, 12.5% and 15.6% respectively were not clinically cured at Day 14 even though they were without treatment failure by Day 6. Conclusions More intensive follow-up of children with chest-indrawing pneumonia and comorbidities who do not have danger signs may be beneficial. |
| اللغة: | English |
| تدمد: | 2047-2986 2047-2978 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64258057f59aa088a84669410fdc9238 http://europepmc.org/articles/PMC7979154 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....64258057f59aa088a84669410fdc9238 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20472986 20472978 |
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