Busulfan systemic exposure and its relationship with efficacy and safety in hematopoietic stem cell transplantation in children: A Meta-Analysis
| العنوان: | Busulfan systemic exposure and its relationship with efficacy and safety in hematopoietic stem cell transplantation in children: A Meta-Analysis |
|---|---|
| المؤلفون: | Libo Zhao, Jingru Zhang, Jiapeng Li, Yunjiao Wu, Changqing Yang, Duanfang Fan, Xinying Feng, Guanghua Zhu |
| المصدر: | BMC Pediatrics BMC Pediatrics, Vol 20, Iss 1, Pp 1-11 (2020) |
| بيانات النشر: | Research Square Platform LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Transplantation Conditioning, Efficacy, Adolescent, Veno-occlusive disease, medicine.medical_treatment, Hematopoietic stem cell transplantation, Review, Cochrane Library, law.invention, Area under the concentration-time curve, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, medicine, Humans, Dosing, Prospective Studies, Adverse effect, Child, Busulfan, business.industry, Incidence (epidemiology), Incidence, lcsh:RJ1-570, Hematopoietic Stem Cell Transplantation, Infant, lcsh:Pediatrics, Meta-analysis, 030220 oncology & carcinogenesis, Child, Preschool, Pediatrics, Perinatology and Child Health, business, 030215 immunology, medicine.drug |
| الوصف: | Background Busulfan (Bu) is a key component of several conditioning regimens used before hematopoietic stem cell transplantation (HSCT). However, the optimum systemic exposure (expressed as the area under the concentration-time curve [AUC]) of Bu for clinical outcome in children is controversial. Methods Research on pertinent literature was carried out at PubMed, EMBASE, Web of science, the Cochrane Library and ClinicalTrials.gov. Observational studies were included, which compared clinical outcomes above and below the area under the concentration-time curve (AUC) cut-off value, which we set as 800, 900, 1000, 1125, 1350, and 1500 μM × min. The primary efficacy outcome was notable in the rate of graft failure. In the safety outcomes, incidents of veno-occlusive disease (VOD) were recorded, as well as other adverse events. Results Thirteen studies involving 548 pediatric patients (aged 0.3–18 years) were included. Pooled results showed that, compared with the mean Bu AUC (i.e., the average value of AUC measured multiple times for each patient) of > 900 μM × min, the mean AUC value of Conclusions In children, Bu mean AUC above the cut-off value of 900 μM × min (after every 6-h dosing) was associated with decreased rates of graft failure, while the cut-off value of 1350 μM × min were associated with increased risk of VOD, particularly for the patients without VOD prophylaxis therapy. Further well-designed prospective and multi centric randomized controlled trials with larger sample size are necessary before putting our result into clinical practices. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645d07a6c64b1bd2bf2376816b28cacf https://doi.org/10.21203/rs.2.11400/v1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....645d07a6c64b1bd2bf2376816b28cacf |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |