التفاصيل البيبلوغرافية
العنوان:
Long-chain formoterol analogues: an investigation into the effect of increasing amino-substituent chain length on the β2-adrenoceptor activity
المؤلفون:
Robin Alec Fairhurst , David Beer , Diana Janus , David Bentley , Lynne Jordan , Claire Hayden , Peter Gedeck , Kirsty Smithies , Sandra Haberthuer , Christine Lewis , Ian N. Bruce , Vahid Alikhani , Bernard Cuenoud , Elke Wissler
المصدر:
Bioorganic & Medicinal Chemistry Letters . 14:4705-4710
بيانات النشر:
Elsevier BV, 2004.
سنة النشر:
2004
مصطلحات موضوعية:
Time Factors , medicine.drug_class , Stereochemistry , Guinea Pigs , Clinical Biochemistry , Substituent , Pharmaceutical Science , Ether , Carboxamide , In Vitro Techniques , Biochemistry , Chemical synthesis , Structure-Activity Relationship , chemistry.chemical_compound , Residue (chemistry) , Formoterol Fumarate , Drug Discovery , medicine , Animals , Humans , Structure–activity relationship , Albuterol , Adrenergic beta-2 Receptor Agonists , Salmeterol Xinafoate , Molecular Biology , Chemistry , Organic Chemistry , Muscle, Smooth , Stereoisomerism , Adrenergic beta-Agonists , Ethanolamines , Molecular Medicine , Formoterol , Muscle Contraction , medicine.drug
الوصف:
The synthesis of a series of long-chain formoterol analogues in which the terminal ether residue of the beta-phenethyl-amino-substituent has been extended beyond the methyl ether residue present in the parent compound are described. Evaluation of these analogues as beta(2)-adrenoceptor agonists was used to provide an insight into the factors controlling the magnitude and duration of receptor activation.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64be52604562ed3f829c3809d0adea29 https://doi.org/10.1016/j.bmcl.2004.06.086
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....64be52604562ed3f829c3809d0adea29
قاعدة البيانات:
OpenAIRE
