Validating a bovine model for lung ultrasound of bronchiolitis
| العنوان: | Validating a bovine model for lung ultrasound of bronchiolitis |
|---|---|
| المؤلفون: | Paul Walsh, Francisco R. Carvallo Chaigneau, Maxim Lebedev, Victoria Mutua, Heather McEligot, Samuel H. F. Lam, Benjamin Hwang, Heejung Bang, Laurel J. Gershwin |
| المصدر: | Journal of ultrasound, vol 25, iss 3 Journal of Ultrasound |
| بيانات النشر: | eScholarship, University of California, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Translational science, Histology, Respiratory Syncytial Virus Infections, Respiratory syncytial virus, Internal Medicine, Animals, Humans, Radiology, Nuclear Medicine and imaging, Lung, Cancer, Pediatric, Original Paper, Lung ultrasound, Lung Cancer, Infant, General Medicine, respiratory system, respiratory tract diseases, Respiratory Syncytial Viruses, Infectious Diseases, Acute Disease, Respiratory, Bronchiolitis, Biomedical Imaging, Cattle |
| الوصف: | Purpose Bronchiolitis is a very common acute lung disease in infants caused commonly by respiratory syncytial virus (RSV). Point-of-care lung ultrasound is increasingly used in clinical care but proof that ultrasound reflects histological disease is lacking. Bovine calves are a good model for RSV bronchiolitis. We answered the following two questions: (1) does point-of-care lung ultrasound reflect lung pathology at the histological level in a bovine calf model of bronchiolitis? and (2) are point-of-care lung ultrasound images in human infants similar to those obtained in calves? Methods We experimentally infected 24 five to six-week-old bovine calves with RSV and compared six window lung ultrasound with lung histology10 days after inoculation. The calves were treated with antivirals and antipyretics leading to variable severity of illness. We used canonical discriminant analysis to determine if abnormal lung ultrasound findings reflected different histological findings. We compared the ultrasounds obtained from the calves with ultrasounds obtained from 10 human infants who were diagnosed clinically with bronchiolitis. Results Canonical discriminant analysis generally demonstrated good class separation based on the maximal severity of ultrasound finding in each acoustic window. Lung ultrasound performed poorly at detecting bronchopneumonia. Bovine ultrasounds looked similar to human infant lung ultrasounds. Conclusion Point-of-care lung ultrasound abnormalities reflect lung pathology at the histological level in a bovine calf model of bronchiolitis. Point-of-care lung ultrasound images in human infants are similar to those obtained in calves. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6542e3fcbf746aa4af327133fcef73ad https://escholarship.org/uc/item/2wg6h2sw |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6542e3fcbf746aa4af327133fcef73ad |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |