The pharmacokinetics of orally administered butylscopolamine in greyhound dogs
| العنوان: | The pharmacokinetics of orally administered butylscopolamine in greyhound dogs |
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| المؤلفون: | Marjaana Viljanto, Melissa Pittorino, Simon Hudson, Stuart W. Paine, T. H. Morris, Sally Colgan, Simon Gower |
| المصدر: | Journal of Veterinary Pharmacology and Therapeutics. 41:790-794 |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 040301 veterinary sciences, Urinary system, 030232 urology & nephrology, Administration, Oral, Urine, 0403 veterinary science, Drug levels, 03 medical and health sciences, Dogs, 0302 clinical medicine, Pharmacokinetics, butylscopolamine, Butylscopolammonium Bromide, Animals, Medicine, plasma, Pharmacology, greyhound, General Veterinary, business.industry, 04 agricultural and veterinary sciences, Anesthesia, Female, Digestive tract, business, pharmacokinetics, Half-Life |
| الوصف: | The oral tablet formulation of butylscopolamine, which is available without prescription, is commonly used by trainers of racing greyhounds to treat functional urethral obstruction. As medication control of butylscopolamine is therefore required for such use to ensure the integrity of greyhound racing an administration study was performed in six greyhounds to determine the pharmacokinetics of orally administered butylscopolamine. A single dose of one 10 mg butylscopolamine tablet was administered orally to simulate this use in greyhound racing. Blood, urine and faeces were collected at regular intervals from the greyhounds for up to 9 days and butylscopolamine concentrations determined. There was some, but very limited, absorption of butylscopolamine, with rapid elimination from plasma with a mean half-life of 2 hours. Urine concentrations initially declined in a similar manner to the plasma pharmacokinetics but then entered a much longer half-life of approximately 50 hours. Faecal concentrations declined to very low levels between 48 and 120 hours. The use of orally administered butylscopolamine for functional urethral obstruction in greyhounds is unjustified due this very limited drug absorption. Medication control of butylscopolamine’s anti-spasmodic effect on the digestive tract is possible by setting screening limits based on the urinary and faecal drug levels as determined in this study. |
| وصف الملف: | application/pdf; PDF |
| تدمد: | 0140-7783 1365-2885 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659ceaca6c06b39b89983ed8e0eff717 https://doi.org/10.1111/jvp.12701 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....659ceaca6c06b39b89983ed8e0eff717 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01407783 13652885 |
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