Safety and efficacy of Cerebrolysin in motor function recovery after stroke: a meta-analysis of the CARS trials
| العنوان: | Safety and efficacy of Cerebrolysin in motor function recovery after stroke: a meta-analysis of the CARS trials |
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| المؤلفون: | Eugene Gusev, Stefan Winter, Johannes C. Vester, Alla Guekht, Wolf-Dieter Heiss, Dafin F. Muresanu, Volker W. Rahlfs, Herbert Moessler, Edith Doppler, Volker Hoemberg, Ovidiu Bajenaru, Bogdan Ovidiu Popescu |
| المصدر: | Neurological Sciences |
| بيانات النشر: | Springer Milan, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | medicine.medical_specialty, Neurology, medicine.medical_treatment, Dermatology, Motor Activity, Placebo, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Recovery, Statistical significance, medicine, Humans, 030212 general & internal medicine, Amino Acids, Stroke, Randomized Controlled Trials as Topic, Rehabilitation, Cerebrolysin, Stroke Rehabilitation, General Medicine, Recovery of Function, medicine.disease, Psychiatry and Mental health, Meta-analysis, Neuroprotective Agents, chemistry, Relative risk, Physical therapy, Original Article, Neurology (clinical), Early benefit, Psychology, 030217 neurology & neurosurgery, NIHSS |
| الوصف: | This meta-analysis combines the results of two identical stroke studies (CARS-1 and CARS-2) assessing efficacy of Cerebrolysin on motor recovery during early rehabilitation. Cerebrolysin is a parenterally administered neuropeptide preparation approved for the treatment of stroke. Both studies had a prospective, randomized, double-blind, placebo-controlled design. Treatment with 30 ml Cerebrolysin once daily for 3 weeks was started 24–72 h after stroke onset. In addition, patients participated in a standardized rehabilitation program for 21 days that was initiated within 72 h after stroke onset. For both studies, the original analysis data were used for meta-analysis (individual patient data analysis). The combination of these two studies by meta-analytic procedures was pre-planned, and the methods were pre-defined under blinded conditions. The nonparametric Mann-Whitney (MW) effect size of the two studies on the ARAT score on day 90 indicated superiority of Cerebrolysin compared with placebo (MW 0.62, P |
| اللغة: | English |
| تدمد: | 1590-3478 1590-1874 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e0d7807fc28a3ee24413c3c5166106 http://europepmc.org/articles/PMC5605586 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....65e0d7807fc28a3ee24413c3c5166106 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15903478 15901874 |
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