Alcohol Drinking and One-Carbon Metabolism-Related Gene Polymorphisms on Pancreatic Cancer Risk
| العنوان: | Alcohol Drinking and One-Carbon Metabolism-Related Gene Polymorphisms on Pancreatic Cancer Risk |
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| المؤلفون: | Takeshi Suzuki, Miki Watanabe, Takakazu Kawase, Tsuneya Nakamura, Hideo Tanaka, Nobumasa Mizuno, Keitaro Matsuo, Akira Sawaki, Kenji Yamao, Kazuo Tajima, Akio Hiraki |
| المصدر: | Cancer Epidemiology, Biomarkers & Prevention. 17:2742-2747 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, Risk, medicine.medical_specialty, Pancreatic disease, Alcohol Drinking, Genotype, Epidemiology, 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase, Gastroenterology, Japan, Internal medicine, Pancreatic cancer, medicine, Humans, Methylenetetrahydrofolate Reductase (NADPH2), Aged, Chi-Square Distribution, Polymorphism, Genetic, biology, business.industry, Cancer, Thymidylate Synthase, Odds ratio, (Methionine synthase) reductase, Middle Aged, medicine.disease, MTRR, Ferredoxin-NADP Reductase, Pancreatic Neoplasms, Logistic Models, Endocrinology, Oncology, Case-Control Studies, Methylenetetrahydrofolate reductase, biology.protein, Female, business |
| الوصف: | Effect of alcohol consumption on pancreatic cancer risk has been investigated in many studies, but results have been inconsistent. We conducted a case-control study to assess the effect of alcohol on pancreatic cancer in conjunction with polymorphisms in one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G), and thymidylate synthase (TS) variable number of tandem repeat. A total of 157 pancreatic cancer patients and 785 age- and sex- matched control subjects were genotyped for polymorphisms. Odds ratios (OR) with 95% confidence intervals (95% CI) were estimated using unconditional logistic models adjusted for potential confounders. Heavy alcohol drinking was marginally associated with an increased risk of pancreatic cancer (OR, 1.90; 95% CI, 1.00-3.62). None of the polymorphisms showed any significant effect on pancreatic cancer risk by genotype alone. In stratified analysis, effect of alcohol consumption on pancreatic cancer was observed in individuals with the MTHFR 667 CC, MTR 2756 AA, or MTRR 66 G allele. OR (95% CI) of pancreatic cancer for heavy drinkers compared with never drinkers was 4.50 (1.44-14.05) in the MTHFR 667 CC genotype, 2.65 (1.17-6.00) in the MTR 2756 AA genotype, and 3.35 (1.34-8.36) in the MTRR 66 G allele carriers. These results suggest that the folate-related enzyme polymorphism modifies the association between drinking habit and pancreatic cancer risk. (Cancer Epidemiol Biomarkers Prev 2008;17(10):2742–7) |
| تدمد: | 1538-7755 1055-9965 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662e5653a83b20f9fea80c6632389cce https://doi.org/10.1158/1055-9965.epi-08-0470 |
| رقم الأكسشن: | edsair.doi.dedup.....662e5653a83b20f9fea80c6632389cce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387755 10559965 |
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