Curcumin and Salsalate Suppresses Colonic Inflammation and Procarcinogenic Signaling in High-Fat-Fed, Azoxymethane-Treated Mice
| العنوان: | Curcumin and Salsalate Suppresses Colonic Inflammation and Procarcinogenic Signaling in High-Fat-Fed, Azoxymethane-Treated Mice |
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| المؤلفون: | Jimmy W. Crott, Joel B. Mason, Gar Yee Koh, Xian Wu, Sanyuan Tang, Anna C. Pfalzer, Mohsen Meydani, Michael Thomas |
| المصدر: | Journal of Agricultural and Food Chemistry. 65:7200-7209 |
| بيانات النشر: | American Chemical Society (ACS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Curcumin, Calorie, Colorectal cancer, Anti-Inflammatory Agents, Azoxymethane, Inflammation, Pharmacology, Diet, High-Fat, Dietary Polyphenol, Proinflammatory cytokine, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, parasitic diseases, Salsalate, medicine, Animals, Humans, Interleukin-6, NF-kappa B, food and beverages, General Chemistry, medicine.disease, Salicylates, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Immunology, medicine.symptom, Colorectal Neoplasms, General Agricultural and Biological Sciences, medicine.drug |
| الوصف: | High-fat diets (HFDs) and excess adiposity increase proinflammatory cytokines in the colon, altering gene expression in a manner that promotes the development of colorectal cancer (CRC). Thus, compounds that reduce this biochemical inflammation are potential chemopreventive agents. Curcumin (CUR), a dietary polyphenol, and salsalate (SAL), a non-steroidal anti-inflammatory drug, are both anti-inflammatories. We investigated the inhibitory effects of CUR with or without SAL on inflammatory cytokines and procarcinogenic signaling in azoxymethane (AOM)-treated A/J mice. A sub-tumorigenic AOM dose was chosen to produce a biochemical and molecular procarcinogenic colonic environment without tumors. Mice were fed either a HFD (60% of kilocalories) or low-fat diet (LFD) (10% of kilocalories). One HFD treatment group received 0.2% CUR in the diet; one received 0.2% CUR + 0.15% SAL; and one received 0.4% CUR + 0.3% SAL. The HFD mice developed 30% greater fat mass than the LFD mice (p0.05). The colonic concentrations of interleukin-1β (IL-1β) and interleukin-6 (IL-6) in the HFD mice were decreased by 50-69% by the high-dose combination regimen (p0.015). Only the combination regimens significantly suppressed phosphorylation of protein kinase B (Akt) and nuclear factor-κB (NF-κB) p65 (p0.044). The combination of CUR and SAL reduces the concentration of proinflammatory cytokines and diminishes activation of Akt and NF-κB more effectively than CUR alone, providing a scientific basis for examining whether this combination mitigates the risk of CRC in obese individuals. |
| تدمد: | 1520-5118 0021-8561 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669655ea0ced725d86b7f24c66d334b7 https://doi.org/10.1021/acs.jafc.7b02648 |
| رقم الأكسشن: | edsair.doi.dedup.....669655ea0ced725d86b7f24c66d334b7 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205118 00218561 |
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