Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future Perspectives
| العنوان: | Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future Perspectives |
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| المؤلفون: | Michael A. Morgan, Dorota Kaniowska, Martin Bentler, Hildegard Büning, Ulrich T. Hacker |
| المصدر: | Cancers, Vol 12, Iss 1889, p 1889 (2020) Cancers |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Tumor angiogenesis, Cancer Research, CAR-T cells, Genetic enhancement, adeno-associated virus (AAV) vectors, Gene transfer, Review, Computational biology, medicine.disease_cause, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, vaccine, Medicine, Vector (molecular biology), transductional targeting, Adeno-associated virus, business.industry, apoptosis, Cancer, tumor angiogenesis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, transcriptional targeting, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer gene, immunotherapy, Car t cells, business, hallmarks of cancer |
| الوصف: | Adeno-associated virus (AAV) vectors have gained tremendous attention as in vivo delivery systems in gene therapy for inherited monogenetic diseases. First market approvals, excellent safety data, availability of large-scale production protocols, and the possibility to tailor the vector towards optimized and cell-type specific gene transfer offers to move from (ultra) rare to common diseases. Cancer, a major health burden for which novel therapeutic options are urgently needed, represents such a target. We here provide an up-to-date overview of the strategies which are currently developed for the use of AAV vectors in cancer gene therapy and discuss the perspectives for the future translation of these pre-clinical approaches into the clinic. |
| تدمد: | 2072-6694 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c4c932399b8406d91a9b82b408842f https://doi.org/10.3390/cancers12071889 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....66c4c932399b8406d91a9b82b408842f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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